The genomes of people who have both autism and intellectual disability have more regions that may harbor recessive mutations than those of their unaffected siblings, according to a study published 11 July in the American Journal of Human Genetics.
Spectrum: Autism Research News
Tag: Simons Simplex Collection
To better understand and treat nonverbal autism, the field must paradoxically move beyond focusing on speech production, say many researchers. Emerging research suggests that seemingly unrelated issues such as motor skills and joint attention may instead be key.
About one in ten women who have a child with autism have immune molecules in their bloodstream that react with proteins in the brain, according to a study published 20 August in Molecular Psychiatry.
Children with autism have more copies of some chromosomal regions than controls do, according to a study published 19 April in Human Molecular Genetics. This is true even after excluding the regions that are the most likely to lead to autism.
Most children with autism who have language delay at age 4 are able to speak later in childhood, according to a study published in the April issue of Pediatrics.
Girls with autism carry more mutations than do boys with the disorder, and show greater differences in brain activity and response to social cues, according to several preliminary studies presented at the 2013 International Meeting for Autism Research in San Sebastián, Spain.
A boy with a rare deletion in chromosome 3 was diagnosed with autism and psychotic symptoms by age 5, according to a case report published 26 February in the American Journal of Medical Genetics Part A. He is the second identified individual with this deletion who has these symptoms, which are exceedingly rare in combination.
Small regions of DNA that are structurally prone to deletions and duplications are unlikely to play a major role in autism, according to research published 7 February in the American Journal of Human Genetics.
Individuals who have childhood-onset schizophrenia carry more DNA deletions and duplications associated with other disorders, such as autism, than their unaffected siblings do. The unpublished research was presented 16 January at the Salk Institute, Fondation IPSEN and Nature Symposium on Biological Complexity in La Jolla, California.