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Tag: signaling imbalance

May 2021
Neurons in red and green
News

‘Neurons on a chip’ reveal patterns across autism-linked conditions

by  /  7 May 2021

Activity patterns of neuronal networks link different genetic subtypes of autism that have similar traits, according to new unpublished research.

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brainstem of rats in red, green and blue highlight higher levels of GABA.
News

GABA agonist rescues auditory hypersensitivity in rats missing autism-linked gene CNTNAP2

by  /  3 May 2021

The investigational drug arbaclofen may right an imbalance between inhibitory and excitatory signaling in the animals’ brains.

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April 2021
Person itching back of neck.
News

Sensory issues linked to heart-rate differences in autistic youth

by  /  5 April 2021

Autistic children with sensory issues show more intense physiological reactions to unpleasant sounds and other sensations than their non-autistic peers do, a new study shows.

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January 2021
neurons in mice
News

Sensory perception, cell signals disrupted in people and mice missing autism gene

by  /  13 January 2021

People and mice with only one working copy of the autism gene SYNGAP1 may have trouble processing sights and sounds.

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November 2020
SYNGAP1 protein between neurons.
News

Reactions from the 2020 SYNGAP1 Scientific Conference

by  /  25 November 2020

Spectrum is covering the 2020 International SYNGAP1 Scientific Conference, which took place virtually because of the coronavirus pandemic. Here we’re highlighting researchers’ reactions to noteworthy presentations.

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September 2020
Brain images showing differences in signaling in autistic and normal brains.
News

Brain signal imbalance tracks with sex and with camouflaging autism traits

by  /  17 September 2020

Autistic men show a greater imbalance between excitatory and inhibitory signaling in the brain than autistic women do, which could explain sex differences in ‘camouflaging.’

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Neurons in a macaque cortex express parvalbumin in red.
News / Toolbox

Virus-based method manipulates inhibitory neurons in brains

by  /  9 September 2020

A new viral tool can selectively control different types of neurons that dampen brain activity in rodents, monkeys and people.

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August 2020
Micrograph of neurons in mouse brain.
News

Inside scientists’ quest to map, modulate social circuits in autism

by  /  17 August 2020

A growing number of studies are revealing circuits that may underlie social challenges in autism — and how to fine-tune them.

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May 2020
News / Toolbox

Ultra-sensitive protein activates neurons in response to external light

by  /  27 May 2020

A new, minimally invasive technique allows researchers to activate neurons in the brains of mice and monkeys by using a light source located outside of the head.

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December 2019
Features / Special Reports / 2019: Year in review

Five hot topics in autism research in 2019

23 December 2019

This year’s hot topics in autism research center around brain organoids, heart rate, the gut microbiome, treatment timing and early detection.

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