Tag: signaling imbalance

April 2018
Opinion / Q&A

Autism genes assign starring role to support cells in brain

by  /  24 April 2018

Genes linked to autism are critical to the development of star-shaped brain cells called astrocytes, suggesting a key role for the cells in the condition.

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January 2018
Mice lacking one copy of MEF2C have fewer neurons (red and green, right) in the hippocampus than controls do (left).
News

Modified Alzheimer’s drug may treat some forms of autism

by  /  18 January 2018

A fusion of two existing drugs alleviates autism-like features in a mouse model of the condition.

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Neurons missing a part of chromosome 16 (left) are larger and have more branches than control neurons (middle); neurons with duplications of the region are small and sport short dendrites (right).
News

Lab-grown neurons showcase effects of autism mutations

by  /  15 January 2018

Neurons derived from people with mutations linked to autism display diverse abnormalities that may help explain the origins of these individuals’ features.

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black rat and white rat
News

Anxiety drug reverses problems in mice with autism mutation

by  /  4 January 2018

A widely used treatment for anxiety can eliminate some of the cognitive and social problems seen in mice missing a copy of ARID1B, a gene associated with autism.

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August 2017
Week of AugustAug
7th
2017
News / Spotted

Off-key outcomes; visualizing variants; urine indifference and more

by  /  11 August 2017

Music therapy proves ineffective for autism, brain structures differ with 16p11.2 duplications and deletions, and mice missing NLGN3 may influence the sociability of their littermates.

2 Comments
News

Flash of light shifts social behavior in autism mice

by  /  2 August 2017

Turning on a set of neurons that dampen brain activity improves social behavior in a mouse model of autism; turning off neurons that excite brain activity does the same thing.

2 Comments
July 2017
News

Antidepressant eases some autism features in mice

by  /  28 July 2017

A drug that keeps neurons bathed in the chemical messenger serotonin prevents social abnormalities in a mouse model of dup15q syndrome.

0 Comments
News

Drug that shifts brain’s signaling balance could treat autism

by  /  20 July 2017

A drug that alters the balance of two key chemical messengers in the brain may help treat autism, suggests a proof-of-principle study.

1 Comment
March 2017
News

In trials, repurposed drug shows promise for autism

by  /  27 March 2017

A drug used to treat excessive swelling seems to ease autism features in some children on the spectrum.

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February 2017
News

Distinct mutations in sodium channel trigger autism, epilepsy

by  /  8 February 2017

Some mutations in a gene called SCN2A make neurons less excitable and are linked to autism; others have the opposite effect and may cause seizures during infancy.

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