Some social issues in DYRK1A model mice stem from faulty inhibitory circuits
Alterations in inhibitory circuits and difficulties in social recognition characterize mice missing one copy of DYRK1A, a gene linked to autism.
Alterations in inhibitory circuits and difficulties in social recognition characterize mice missing one copy of DYRK1A, a gene linked to autism.
An imbalance in the number of excitatory neurons in early brain development may account for the difference.
Synaptic changes in the brain region could drive a core trait of fragile X syndrome, a new mouse study suggests.
A protective pathway that pauses protein synthesis is muted in a mouse model of fragile X syndrome, according to a new study.
Autistic children taking the drug showed improvements in some behaviors but not in their social skills.
Cannabidiol (CBD) blocks the action of a molecule that drives an overexcitability feedback loop in a rodent model of epilepsy.
Conventional optogenetic manipulations to excite or inhibit neurons stop when the light switches off. A new approach makes the changes last.
People’s brains have a larger network of inhibitory interneurons than mouse brains do, according to a new study. Changes to that network could contribute to autism or other conditions, says lead investigator Moritz Helmstaedter.
Long cast in supporting roles in the brain, astrocytes are now emerging as primary players in certain characteristics of autism and related conditions.
Mutations in all three accelerate the maturation of inhibitory neurons, which could upset the brain’s balance of excitation and inhibition early in development.