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Tag: SHANK3

November 2010
News

Large postmortem brain study traces spine shapes

by  /  16 November 2010

The brains of people with autism have abnormally dense and stubby dendritic spines, the neuronal projections that receive electrical signals, according to data presented Monday at the Society for Neuroscience annual meeting in San Diego.

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News

Video: Of mice and men

by  /  16 November 2010

If you give most mice a choice between sniffing a new playmate and a new object, most will choose the new playmate every time. But not BTBR or SHANK3 mutant mice, which spend less time engaging in social interactions with other mice. Does that mean these mice have autism?

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News

Mutant mouse pins PSD-95 in Williams syndrome

by  /  2 November 2010

Mice missing a large protein at the junction between neurons show motor impairments, anxiety and increased social behaviors, according to a study in the American Journal of Psychiatry. The protein, postsynaptic density-95 or PSD-95, is part of a key molecular bridge connecting other proteins linked to autism.

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October 2010
News

Cognition and behavior: SHANK1 mutant mice do not model autism

by  /  25 October 2010

SHANK1 — a member of a family of proteins linked to autism — does not cause autism-like social deficits when mutated in mice, according to a study published online in September in Brain Research.

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August 2010
News

Brain’s adaptability begins at single synapse

by  /  10 August 2010

Researchers have uncovered an important molecular piece of a learning mechanism that occurs at the junction between neurons. The findings, which may help understand how the brain is disrupted in disorders such as autism, appear in the 24 June issue of Neuron.

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July 2010
News

Synaptic defects link autism, schizophrenia

by  /  2 July 2010

Several independent groups have found previously unknown risk genes for autism, schizophrenia and mental retardation. The candidate genes have one thing in common: they encode proteins that are needed for the healthy function of synapses, the junctions between neurons.

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February 2010
News / Toolbox

Super-cool synapses

by  /  1 February 2010

A chilling new technique shows the intricate and coordinated activity of previously mysterious pieces of the synapse, the all-important junction between neurons that allows cells to talk to each other.

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November 2009
News

Autism marked by altered trajectory of brain growth

by  /  3 November 2009

Although the head overall is bigger in some children with autism, researchers have found more informative differences in size — some smaller, some larger — across regions of the brain.

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October 2009
News

Gene on chromosome 22 leads to autism mouse model

by  /  22 October 2009

Mice lacking a gene located in the chromosomal region 22q13 — which has been linked to autism — have motor learning and social deficits reminiscent of the disorder, according to unpublished findings presented in a poster session yesterday at the Society for Neuroscience meeting in Chicago.

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January 2009
Opinion / Viewpoint

The 2003 paper linking neuroligins to autism

by ,  /  12 January 2009

In 2003, Stephane Jamain and his colleagues reached a breakthrough by taking a candidate approach to the X chromosome, and linking members of the neuroligin protein family to autism.

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