The function of microglia and astrocytes in the brain may mediate the intersection of sex-differential biology and autism biology.
Spectrum: Autism Research News
The findings, based on Swedish national registry data, suggest a critical need to expand mental health services for autistic people.
The rare variants are also linked to ADHD and Tourette syndrome, two other conditions that disproportionately affect boys and men.
Siblings of autistic females are more likely to have autism than siblings of autistic males are, and mothers of autistic children carry more common, autism-linked variants than fathers do.
The male sex bias in autism may in large part be a product of how common diagnostic tools measure traits in boys versus girls at a single point in time, according to a new study.
Different combinations of common, rare, inherited and spontaneous mutations may explain why traits vary so widely among autistic people.
The co-occurring conditions may stem from the heightened stress people in minority communities experience.
The sex-specific effects may help elucidate why the small number of boys with DDX3X syndrome are born to unaffected mothers.