Tag: sequencing

April 2010
News

Future of autism genetics is all in the family

by  /  30 April 2010

Two independent teams have identified the genetic culprits of three rare, inherited diseases by sequencing the genomes of several members of the same family. As the cost of whole-genome sequencing plummets, this family-based approach will reveal candidate genes not just for rare diseases but for common, complex disorders such as autism, experts say.

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News

Researchers probe genetic overlap between ADHD, autism

by  /  22 April 2010

Attention deficit hyperactivity disorder (ADHD) and autism may have more in common than childhood onset and a few similar symptoms. New research suggests the conditions share genetic roots.

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Opinion

All together now?

by  /  19 April 2010

On 7 April, a group of investigators conducting autism genome sequencing projects met at the New York Academy of Medicine, aiming to establish the ground rules for a potential Autism Sequencing Consortium.

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March 2010
Opinion

Happy birthday, genome

by  /  31 March 2010

This summer will mark ten years since scientists sequenced the human genome. What have we gained from knowing those 3 billion base pairs?

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December 2009
News

Mounting evidence fingers mitochondria in autism risk

by  /  8 December 2009

Using new genetic screening technology, a few research groups are finding that a surprisingly large number of children with autism — at least five percent — have an underlying problem with their mitochondria, the energy factories of the cell.

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October 2009
Opinion

Lessons from an obscure tumor

by  /  28 October 2009

There are well-established paternal age effects in diseases less common than autism. A new paper in Nature Genetics explains how the effects might arise, and it involves a kind of tumor you’ve probably never heard of.

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News

Video: NIH director has big plans for autism research

by  /  19 October 2009

National Institutes of Health director Francis Collins talks about the agency’s upcoming plans for “beefing up” autism research, including more than $100 million each year in grants for the field.

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October 2008
Opinion / Viewpoint

In search of meaningful copy number variations

by  /  24 October 2008

In the past few months, researchers have published dozens of reports linking single-nucleotide polymorphisms (SNPs) with susceptibility to a range of common diseases.

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March 2008
News

The case for copy number variations in autism

by  /  17 March 2008

Following a series of papers in the past two years, what seems irrefutable is that copy number variations ― in which a particular stretch of DNA is either deleted or duplicated ― are important in autism.

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December 2007
News / Profiles

Aravinda Chakravarti: Not everything we do is biology

by  /  7 December 2007

Stylianos Antonarakis still vividly remembers the thorny statistical problem that had vexed him for several months in 1982. Antonarakis, then a postdoctoral fellow at Johns Hopkins University, had turned to his colleagues at Hopkins, but none of them had been able to solve the problem.

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