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Spectrum: Autism Research News

Tag: sequencing

November 2021
A gloved-hand holds up a vial against a background of colorful lights that represent a sequenced genome.

Genetic effects stack up in some people with autism

by  /  23 November 2021

Rare variants that alter the expression of genes in the brain contribute to autism in people who also have a rare autism-linked mutation, according to a new study.

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October 2021
Illustration: a 3D DNA molecule sits on a gridded background, with yellow paper rays arrayed around it.

Subset of autism cases linked to mutations in noncoding genome

by  /  20 October 2021

Autism involves mutations in noncoding portions of the genome in at least 3 percent of people with the condition. The mutations occur in regions that help regulate known autism-linked genes.

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September 2021
Four brains showing areas affected by the X chomosome in yellow

X chromosome exerts extra influence on brain development

by  /  15 September 2021

The X chromosome holds stronger-than-expected genetic sway over the structure of several brain regions. The genes that may underlie this oversized influence have ties to autism.

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July 2021
Colorful, playful illustrated scene of ewborns on a conveyor belt moving past researchers holding a long, long list.

The push to screen newborns for rare autism-linked genetic conditions

by  /  28 July 2021

As treatments for some autism-linked genetic conditions inch closer to the clinic, researchers are talking more urgently about screening all newborns for such conditions.

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Ultra-rare variants point to new autism candidate genes

by  /  26 July 2021

A large, whole-genome sequencing study of families yields insights into ultra-rare genetic variants that contribute to autism.

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May 2021
DNA helix inside the human body

Autism genetics, explained

by  /  28 May 2021

The more scientists dig into DNA, the more intricate its contribution to autism seems to be. Here, we unravel the complex genetics of autism.

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Computer screenshot showing bands of colour resulting from sequenced DNA.

Largest autism genetics analysis to date uncovers more high-confidence candidates

by  /  6 May 2021

The largest-yet study of genetic data from autistic people has identified 255 genes associated with the condition.

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April 2021
Colorful RNA in mouse brain slice

Tissue-swelling method divulges RNA locations, sequences in cells

by  /  28 April 2021

A technique that expands tissue before spotting and sequencing RNA — the molecular messenger for DNA — enables researchers to see where particular genes are expressed in cells.

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single celled zygote seen as a colorful cluster of dots, next to a four cell embryo, visualized in the same way.

Intact-cell sequencing lays bare new view of genome structure

by  /  22 April 2021

The technique enables researchers to sequence the DNA of an intact cell, providing a unique view of the genome’s organization inside the nucleus.

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March 2021
Brain made of DNA strands on a background of molecule shapes

There are no autism-specific genes, just brain genes

by ,  /  23 March 2021

There is not yet a single example of a gene that, when mutated, increases the likelihood of autism but not of other neurodevelopmental conditions, including intellectual disability.

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