Valproate fate
A new rat study shows that the precise timing of early valproate exposure, an autism risk factor, can have a big influence on behavior later in development.
A new rat study shows that the precise timing of early valproate exposure, an autism risk factor, can have a big influence on behavior later in development.
A promising approach to treating fragile X syndrome could benefit people even after the critical window of early brain development, and alleviate core symptoms of autism, according to two studies published this month.
Childhood disintegrative disorder represents a distinct entity within the autism spectrum and it should remain a separate diagnostic category, says Kevin Pelphrey.
Mutations in more than 100 autism-associated genes lead to shared neurobiological deficits in mice, including alterations in the shape of their brains and changes to the electrical properties of neurons, according to a study published 20 February in Molecular Autism.
Two mutations in an autism-associated gene, neurexin-1, may have combined to cause autism in one man, whereas family members with only one of the two mutations have other neurological disorders, according to a study published 15 February in the American Journal of Medical Genetics Part B.
Researchers have identified a new mechanism that may underlie a runaway cell signaling pathway in fragile X syndrome. The results were published 22 January in Nature Neuroscience.
Two genes may be responsible for autism symptoms in mice with extra copies of the Rett syndrome gene, according to a study published 8 January in Nature Genetics.
Mice engineered to carry a Rett syndrome mutation only in neurons are prone to an irregular heartbeat that can lead to sudden death, according to a study published 14 December in Science Translational Medicine.
Duplication of a region on the X chromosome leads to a genetic disorder characterized by severe autism, according to a study published 25 November in Annals of Neurology.
Lowering the levels of a protein associated with Alzheimer’s disease can rescue symptoms of fragile X syndrome in mice, according to a study published 26 October in PLoS One.