Researchers make neurons directly from skin cells
Human skin cells can be converted directly into functional neurons, bypassing a reprogramming step that is part of the typical procedure, according to a study published 26 May in Nature.
Human skin cells can be converted directly into functional neurons, bypassing a reprogramming step that is part of the typical procedure, according to a study published 26 May in Nature.
Several targeted trials on drugs that treat fragile X syndrome are under way. But accurate endpoints to measure the drugs’ effectiveness are crucial, argues developmental and behavioral pediatrician Randi Hagerman.
Children with autism have fewer DNA modifications that regulate gene expression compared with healthy siblings and controls, and show evidence of DNA damage, according to a study published 26 April in the Journal of Autism and Developmental Disorders.
A new study provides the first functional link between the schizophrenia risk gene DISC1 and two candidate genes for autism. DISC1 significantly alters expression of NRXN1 and NRXN2 at key phases of development, according to a brief report in the June issue of Molecular Psychiatry.
The placenta regulates the levels of the neurotransmitter serotonin in the brains of mice at a key stage in embryonic development, according to a study published 21 April in Nature. The results suggest that the fetal environment can influence the long-term mental health of children, including whether they later develop autism or schizophrenia.
Researchers have devised a way to inactivate genes in zebrafish embryos, creating a collection of hundreds of mutant fish lines in which gene function can be explored. The technique was published online 8 May in Nature Methods.
Large studies on the epidemiology and genetics of epilepsy and autism have uncovered commonalities between the two disorders. But scientists are only beginning to untangle the biological roots of the overlap.
Animal research hints that sex hormones may be responsible for the gender bias in autism. More research is needed in people to back this up, says a new review.
Researchers have taken skin cells from individuals with schizophrenia, bathed them in chemical cocktails and coaxed them to develop into neurons, according to a paper published 13 April in Nature.
Identical twins can be genetically different, which could explain why they do not always share disorders such as schizophrenia or autism, according to a study published in March in PLoS One.