Autistic people and their families are increasingly experimenting with marijuana to try to ease problems such as insomnia, epilepsy and chronic pain — and traits of autism. But there is little evidence for its safety or effectiveness.

Mutations in the MECP2 gene, which are associated with autism and Rett syndrome, interfere with a cell’s ability to form droplets of DNA that silence gene expression.

Researchers have used the gene-editing tool CRISPR to disable the MECP2 gene in marmoset embryos. The six such marmosets created seem to recapitulate aspects of Rett syndrome.

A single dose of cannabidiol, a component of marijuana, eases seizures and improves learning and sociability in mice with mutations in an autism gene called CDKL5.

Studies of Rett syndrome hint at genes, cells and brain circuits that may be involved in autism — and may pave the way to treatments for both conditions.

Heart-rate patterns and changes in pupil size may herald Rett syndrome, autism or related conditions.

An experimental leukemia drug and a chemical in black pepper ease breathing and movement problems in a mouse model of Rett syndrome.