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Spectrum: Autism Research News

Tag: postsynaptic density

December 2017
Week of DecemberDec

Pruning protein; cultural connection; cannabis consent and more

by  /  8 December 2017

A pruning protein reshapes neurons, culture should be a consideration in trials of autism treatments, and another U.S. state adds autism to the list of indications for medical cannabis.

September 2017
Illustration of Protein factories at neuronal junctions

Protein factories at neuronal junctions take center stage in autism

by ,  /  12 September 2017

Some genes linked to autism regulate the production of proteins at neuronal junctions, suggesting that disrupted protein synthesis contributes to the condition.

September 2016

Proteins that spark learning may play key part in autism

by  /  29 September 2016

A new study ties autism risk to a core team of proteins that facilitate neuronal signaling as an animal learns.

June 2015

Cell skeleton breakdown may spur autism symptoms in mice

by  /  15 June 2015

An autism-linked mutation in the SHANK3 gene alters the protein skeleton of mouse neurons. Repairing the scaffold eases the animals’ social deficits.

December 2014

Method isolates protein complexes from neuronal junctions

by  /  17 December 2014

Researchers have for the first time isolated and characterized protein complexes found at the points of connection between neurons. Mutations in some of these proteins are linked to autism.

June 2014

Large study underscores role of gene copy number in autism

by  /  2 June 2014

People with autism tend to carry mutations that duplicate or delete several genes at once, according to a large study published 1 May in the American Journal of Human Genetics.

November 2012

Brain atlas maps gene expression in three dimensions

by  /  14 November 2012

Researchers have charted patterns of gene expression in a three-dimensional representation of the human brain. The results, published 20 September in Nature, show that different brain regions have distinct molecular and functional roles.

August 2012

Defects in autism risk genes may lead to slower signals

by  /  6 August 2012

Mutations in two genes linked to autism, neurexin and neuroligin, slow down neuronal signaling, according to research published 2 August in Science. Analyzing the mutations in the nematode Caenorhabditis elegans, the study found that mutations in these genes affect signaling in the opposite direction than is typical.

January 2012

Molecular mechanisms: Autism gene tied to neuronal junctions

by  /  24 January 2012

Neurobeachin, or NBEA, an autism–associated gene, may regulate the transport of signaling molecules to neuronal branches, according to a study published 22 November in Nature Communications.

November 2011

Molecular mechanisms: SHANK2 mutants alter synapses

by  /  30 November 2011

Three mutations in SHANK2, an autism-associated gene, each lead to abnormal synapses, the junctions between neurons, according to a study in Human Molecular Genetics.