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Spectrum: Autism Research News

Tag: postmortem brains

May 2022
Color-coded brain images showing reduced thickness of superior frontal gyrus and other regions associated with presence of increased levels of inflammatory moleucle IL-6.

Inflammation may reshape brain regions tied to autism

by  /  6 May 2022

Having a genetic predisposition to inflammation is linked to structural changes in brain regions implicated in neurodevelopmental conditions.

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April 2022

Histone-modifying drug improves autism-like behaviors in mice

by  /  18 April 2022

The experimental compound, called GSK-LSD1, enhances social preferences and reduces repetitive grooming in mice, according to a new study.

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February 2022
Conceptual illustration of female brain versus male brain.

Searching for the biology behind autism’s sex bias

by  /  11 February 2022

The fact that autism seems to affect more boys than girls is often attributed to diagnostic gaps, but the skew remains largely unexplained. Some scientists are turning to basic biology for answers.

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January 2022
Cerebral cortex transcript

Alternate RNA versions of genes may shape autism

by  /  7 January 2022

Autism may involve different levels of RNA isoforms encoded by genes in the brain, which express many more proteins than previously thought.

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December 2021
Illustration of DNA helix highlighting the methylation process.

DNA methylation in autism, explained

by  /  13 December 2021

How chemical tags called methyl groups position themselves on genetic sequences may hint at some of the causes of autism.

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November 2021

New studies reveal how autism might alter synapse formation, pruning

by  /  12 November 2021

The work fills in gaps about how synapses change before and after birth — essential knowledge for understanding whether synapse development differs in autism.

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October 2021
Illustration of large globe shaped like a brain sitting in center of room and showing Latin America prominently.

Diversifying autism brain banks: Q&A with Verónica Martínez-Cerdeño

by  /  25 October 2021

The postmortem brain tissue available for autism research is overwhelmingly from people of Western European heritage. Verónica Martínez-Cerdeño and her colleagues are working to change that.

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February 2021
Oligodendrocyte gene grouping showing network of blue lines connecting the gene names on reddish bubbles.

Differing gene functions across species may pose problems for autism models

by  /  22 February 2021

Misaligned gene expression maps suggest that some autism-linked genes play distinct roles in mouse and human brains.

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December 2020
Brain images color-coded to show structural changes in autism.

Gene expression maps reveal origins of brain changes from autism mutations

by  /  4 December 2020

A new study pinpoints the genes and cell types that may underlie the atypical brain structure seen in people with genetic conditions linked to autism.

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October 2020

Integrating molecular data may reveal subgroups of autism

by  /  30 October 2020

An analysis of four molecular datasets shows a distinct signature, including changes in gene expression and chemical DNA modifications, in some autism brains.

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