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Spectrum: Autism Research News

Tag: parental age

April 2013

Grandfathers’, parents’ ages influence autism risk

by  /  22 April 2013

Two large Scandinavian studies published in March, which together include more than 10,000 children with autism, add to a growing body of research suggesting that older parents are at an increased risk of having children with autism.

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December 2012

Brothers and sisters

by  /  18 December 2012

People with autism have fewer children than average, and so do their brothers, according to a study of Swedes born between 1950 and 1970.

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Genetics: Searching for answers

by  /  6 December 2012

Solving the riddle of autism genetics will require looking beyond the growing list of candidate genes to epigenetics and personalized medicine.

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October 2012

Old mice may pass on ‘epimutations’ to offspring

by  /  14 October 2012

The sperm of old mice has an unusual epigenome, the profile of chemical modifications to the underlying DNA code, according to a poster presented Saturday at the 2012 Society for Neuroscience annual meeting in New Orleans. The findings suggest an explanation for the so-called paternal age effect in autism.

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August 2012

Father’s age dictates rate of new mutations

by  /  23 August 2012

With every passing year, men are increasingly likely to transmit new mutations to their children, according to the largest study yet of the so-called paternal age effect, published yesterday in Nature. The findings could help explain why older men are more likely to have a child with autism or schizophrenia than are younger men, the researchers say.

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Genes and environment are two-way street in autism risk

by  /  21 August 2012

Genes and the environment each influence the role of the other in determining the risk of developing autism. Genetics can determine how susceptible one is to the environment, and environmental factors can influence gene expression and introduce mutations, says immunologist Janine LaSalle.

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April 2012

Large sequencing study ties autism genes to fragile X

by  /  26 April 2012

Children with autism carry twice as many new and damaging genetic mutations as typically developing children, according to a new study published in Neuron. The researchers also identified intriguing genetic links between autism and fragile X syndrome.

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Hundreds of genes involved in autism, sequencing studies say

by  /  4 April 2012

The largest set of exome sequencing studies of children with autism and their families to date has identified a handful of genes that may increase risk of the disorder, according to research published in Nature.

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March 2012

RAS pathway, a potentially unifying theory of autism

by  /  13 March 2012

Dysregulation of the intracellular signaling pathway RAS, a risk factor for idiopathic autism, may provide a unifying theory of the disorder. Although this is not an altogether new hypothesis, several new findings have strengthened the evidence for it considerably.

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Genetics: Maternal and paternal age increase risk of autism

by  /  6 March 2012

The odds of having a child with autism begin to rise at age 35 for both men and women, but that risk does not increase further when both parents are over 35, according to a large study published in the March issue of Annals of Epidemiology.

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