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Tag: oxidative stress

December 2011
News

Molecular mechanisms: Master regulator altered in autism

by  /  16 December 2011

SP1, a protein that regulates the expression of several autism candidate genes, could increase risk of the disorder by simultaneously altering the expression of a number of the genes, according to a study published 24 October in Biological Psychiatry.

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June 2011
News

Molecular mechanisms: Metabolic changes increase risk of autism

by  /  8 June 2011

Children with autism have fewer DNA modifications that regulate gene expression compared with healthy siblings and controls, and show evidence of DNA damage, according to a study published 26 April in the Journal of Autism and Developmental Disorders.

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May 2011
News

Genetics: Metabolism gene trio linked to autism

by  /  13 May 2011

Variants of three genes involved in a metabolic pathway together raise the risk of autism, according to a study published 5 March in the Journal of Neurodevelopmental Disorders.

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News

Molecular mechanisms: Autism candidate recycles neurotoxin

by  /  4 May 2011

An autism-associated gene variant of glyoxalase 1, or GLO1, leads to the buildup of a compound that is toxic to neurons, according to a study published 12 April in Autism Research.

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March 2011
News

New candidate gene may explain male bias of autism

by  /  24 March 2011

A gene that regulates the conversion of testosterone to estrogen in the brain could help explain why males are more susceptible to autism than are females, according to a study published in PLoS One in February.

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News

Mitochondrial function disrupted in children with autism

by  /  17 March 2011

The first study to look at mitochondria — the powerhouses of the cell — in postmortem brain tissue taken from children with autism has found significant abnormalities in their function in some regions of the brain.

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December 2010
News

Defects in mitochondria linked to autism

by  /  3 December 2010

Cells drawn from a small sample of children with autism show defects in the functioning of their mitochondria — structures that produce energy to power cellular functions — according to a study published this week in the Journal of the American Medical Association.

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June 2010
News

Worms set to fill holes in autism research

by  /  14 June 2010

Worms, despite their crude nervous system, can be useful models of the genetic underpinnings of autism, according to unpublished work presented today at a meeting of the Genetics Society of America in Boston.

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October 2009
News

Neuroligin mutation triggers oxidative stress

by  /  20 October 2009

Deleting a neuronal protein associated with autism causes oxidative stress — characterized by an excess of free radicals — which has been linked to diseases such as diabetes and Alzheimer’s, according to new research in worms. The results were presented yesterday at a poster session at the Society for Neuroscience meeting in Chicago.

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