More than 70 percent of individuals lacking the autism-associated 16p11.2 chromosomal region are overweight or obese, according to a study published 20 September in the Journal of Genetics and Genomics.
Spectrum: Autism Research News
Adults with autism are more likely than controls to have certain chronic health conditions, such as high cholesterol, but are less likely to treat these with prescription drugs.
The largest and most ambitious genome-sequencing project to date aims to identify rare variants and study their association to disease traits in 10,000 people.
Researchers have developed standard genetic reference samples that clinicians can use to diagnose Angelman and Prader-Willi syndromes, two disorders associated with the same chromosomal region.
Wendy Chung planned to spend her career in a research lab, identifying rare pathologies. But life had other plans for her.
Deletions on a segment of chromosome 11 are associated with autism, attention problems and obesity, according to a study published in the June issue of the American Journal of Medical Genetics Part A.
Two new studies of families carrying glitches on a region of chromosome 16, which has been strongly associated with autism, reveal the wide range of effects caused by the variant and narrow the list of possible culprit genes.
Copy number variations, or CNVs — duplications or deletions of DNA segments — can influence the expression of unrelated genes on the same chromosome, according to a study published in November in PLOS Biology.
Two independent groups have created mice that have deletions or duplications in a large section of chromosome 16. Each team has produced an animal with a different set of features, some of which — such as large head size and repetitive behaviors — are reminiscent of people with autism.
Two new studies use medical records from countries with nationalized health care to link autoimmune disease and obesity in parents to the likelihood of having a child with autism.