Neurotransmitters
What happens when a histopathologist teams up with computational modelers?
Answers emerge in my chat with Nicola Palomero-Gallagher, a rare example of someone who connects the brain’s microscopic constituents and macroscopic features.
What happens when a histopathologist teams up with computational modelers?
Abundant motor proteins disrupt cries in FOXP2 mice
Knocking down the gene that codes for the proteins normalizes the vocalizations.
Abundant motor proteins disrupt cries in FOXP2 mice
Autism and the cell’s antennae
Many autism-linked genes are somehow tied to cilia, the tiny hair-like sensors that stud a cell’s surface. But the question remains whether, and how, cilia differences contribute to the condition.
Multi-omics study captures CNTNAP2’s far-ranging effects
The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.
Multi-omics study captures CNTNAP2’s far-ranging effects
Tripping over the potential of psychedelics for autism
Drugs such as LSD act primarily on the serotonin system, which is implicated in autism — and some autistic people who experiment with psychoactive compounds report enhanced social connections, among other benefits. But researchers have more questions than answers.
Tripping over the potential of psychedelics for autism
Autism research makes the leap to frogs
Frogs are useful for autism research for a slew of reasons, including the fact that the animals' initial development occurs outside of the mother's body in plain view.
Drugs boost serotonin, socialization in multiple autism mouse models
The finding that MDMA and an experimental serotonin agonist increase sociability across six different model mice suggests that disparate autism-linked mutations converge on the same underlying pathways.
Drugs boost serotonin, socialization in multiple autism mouse models
Neural network captures noisy neurons in autism mouse model
Mice missing the autism-linked gene SHANK3 use more neurons to engage in social behavior than control mice do, reflecting a more disorganized, less efficient brain signaling network.
Neural network captures noisy neurons in autism mouse model
After 60 years, scientists are still trying to crack a mysterious serotonin-autism link
The high levels of serotonin seen in the blood of some autistic people have confounded scientists for more than half a century. Despite so little progress, some researchers refuse to give up.
After 60 years, scientists are still trying to crack a mysterious serotonin-autism link
Stimulant restores cell signaling, eases behavior issues in animals missing autism gene
Worms and zebrafish missing both copies of the gene CHD7 have disrupted cellular signaling, a dearth of inhibitory neurons and behavior changes — all of which are reversed by the stimulant drug ephedrine.
Stimulant restores cell signaling, eases behavior issues in animals missing autism gene
Explore more from The Transmitter
X chromosome inactivation; motor difficulties in 16p11.2 duplication and deletion; oligodendroglia
Here is a roundup of autism-related news and research spotted around the web for the week of 6 May.
X chromosome inactivation; motor difficulties in 16p11.2 duplication and deletion; oligodendroglia
Here is a roundup of autism-related news and research spotted around the web for the week of 6 May.
Decoding flies’ motor control with acrobat-scientist Eugenia Chiappe
The tiny performers steal the show in Chiappe’s sensorimotor-integration lab in Lisbon, Portugal.
Decoding flies’ motor control with acrobat-scientist Eugenia Chiappe
The tiny performers steal the show in Chiappe’s sensorimotor-integration lab in Lisbon, Portugal.
Neuroscience needs a research-video archive
Video data are enormously useful and growing rapidly, but the field lacks a searchable, shareable way to store them.
Neuroscience needs a research-video archive
Video data are enormously useful and growing rapidly, but the field lacks a searchable, shareable way to store them.