Tag: neurexin

November 2010
News

Mutant mouse pins PSD-95 in Williams syndrome

by  /  2 November 2010

Mice missing a large protein at the junction between neurons show motor impairments, anxiety and increased social behaviors, according to a study in the American Journal of Psychiatry. The protein, postsynaptic density-95 or PSD-95, is part of a key molecular bridge connecting other proteins linked to autism.

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October 2010
News

Genetics: New statistical analysis links mutations to disease

by  /  20 October 2010

A new study, published in September in PLOS Genetics, shows the importance of comparing cases to controls when linking mutations to a disorder. The researchers propose a new method of analysis that takes into account the large size of many genes expressed in the brain.

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July 2010
News

Neurexin found to have diverse partners at synapse

by  /  27 July 2010

Scientists have discovered that neurexins — proteins linked to autism — bind to a wide variety of molecules at the junction between neurons. In this complicated system, the breakdown of any one of the parts could lead to improper cell signaling, ultimately giving rise to disease.

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News

Synaptic defects link autism, schizophrenia

by  /  2 July 2010

Several independent groups have found previously unknown risk genes for autism, schizophrenia and mental retardation. The candidate genes have one thing in common: they encode proteins that are needed for the healthy function of synapses, the junctions between neurons.

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May 2010
News

Study implicates cell-adhesion proteins in autism

by  /  18 May 2010

Variations in two genes needed to form connections between brain cells may be associated with autism spectrum disorder, according to a study published 25 March in Molecular Autism. Some variants in the genes seem to increase susceptibility to autism, whereas others protect children from developing the disorder.

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April 2010
News

Scientists finger neurexin 1 defects in autism

by  /  20 April 2010

Several studies in the past year in people, mice and honeybees have tied autism to a protein that helps neurons communicate. Problems with the protein, neurexin 1, are associated with a wide range of autistic behaviors, such as impaired social interactions, anxiety and problems with learning and memory.

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February 2010
News / Toolbox

Super-cool synapses

by  /  1 February 2010

A chilling new technique shows the intricate and coordinated activity of previously mysterious pieces of the synapse, the all-important junction between neurons that allows cells to talk to each other.

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November 2009
Opinion

Double trouble

by  /  17 November 2009

Rare mutations that increase the risk of neuro-psychiatric diseases usually occur in only one copy of a gene. What happens when both copies are mutated?

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News

Variants in synaptic protein linked to autism

by  /  9 November 2009

Scientists have identified several autism-specific variants in a gene that lies within a chromosomal region linked to the disorder, according to a poster presented at the World Congress of Psychiatric Genetics in San Diego.

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October 2009
News

Synaptic proteins help neurons grow

by  /  17 October 2009

Proteins associated with autism mediate the growth of spiny neuronal projections, called dendrites, that form brain circuits in early life, according to unpublished research presented today at the Society for Neuroscience meeting.

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