Molecular mechanisms: DISC1 variants inhibit neurogenesis
Three variants of DISC1, a gene implicated in schizophrenia and autism, may disrupt the formation of new neurons in the brain, according to a study published 17 November in Neuron.
Three variants of DISC1, a gene implicated in schizophrenia and autism, may disrupt the formation of new neurons in the brain, according to a study published 17 November in Neuron.
A new technique efficiently screens for compounds that enhance or inhibit the formation of synapses, the junctions between neurons, according to a study published 25 October in Nature Communications.
Studying the cellular and molecular mechanisms that underlie autism is crucial to advancing our understanding of the disorder, says neuroscientist Eric Kandel.
A large scientific research company debuted seven new rat models of autism Tuesday evening in Washington, D.C. Two of the models, one lacking FMR1 and the other lacking NLGN3, show some unexpected new characteristics.
Neurexins, autism-linked proteins that organize synapses, the junctions between neurons, function in only a subset of cells in the brain, according to data presented in a poster Monday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.
Mice lacking the autism risk gene SHANK2 show social deficits and are extremely hyperactive, according to unpublished research presented Saturday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.
An autism-linked protein helps wire neurons together, according to two studies published in late September.
Stem cells reprogrammed to become neurons can provide a picture of gene expression in neurons that is traditionally available only from brain tissue.
Two autism-associated genes that function at the synapse, the junction between neurons, are associated with severe intellectual disability, according to a study published 9 August in BMC Medical Genetics.
The first study to sequence more than 100 genes on the X chromosome in people with autism or schizophrenia has turned up some promising leads.