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Spectrum: Autism Research News

Tag: neurexin

May 2012

Molecular mechanisms: Mutant mice show signs of autism

by  /  25 May 2012

Mice that are unable to produce a carbohydrate molecule that regulates cell growth show behaviors that resemble the core deficits of autism, according to a study published 27 March in the Proceedings of the National Academy of Sciences.


Genetics: Mutations at neuronal junctions linked to autism

by  /  22 May 2012

Researchers have identified four new mutations in the autism-linked gene neurexin-1 in individuals who have autism and severe intellectual disability, they reported 3 April in Neurobiology of Disease.


Genetics: Study further implicates rare CNVs in autism

by  /  2 May 2012

Individuals with autism are more likely than controls to have small, rare duplications or deletions of stretches of DNA in genes that play a role in dampening signals in the brain, according to a study published 2 April in Molecular Autism.

April 2012

Why oh Y

by  /  24 April 2012

New research on children with extra sex chromosomes points to the Y chromosome’s role in autism.

March 2012

Autism mutations lead to scores of symptoms in rodents

by  /  14 March 2012

Mutations in more than 100 autism-associated genes lead to shared neurobiological deficits in mice, including alterations in the shape of their brains and changes to the electrical properties of neurons, according to a study published 20 February in Molecular Autism.


Genetics: Autism linked to two mutations in same gene

by  /  14 March 2012

Two mutations in an autism-associated gene, neurexin-1, may have combined to cause autism in one man, whereas family members with only one of the two mutations have other neurological disorders, according to a study published 15 February in the American Journal of Medical Genetics Part B.

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Molecular mechanisms: Autism protein forms aggregates

by  /  13 March 2012

DISC1, an autism-associated protein, can form large aggregates that deplete the amount of functional DISC1 in cells, according to a study published 14 February in Human Molecular Genetics.


Looking at autism through the fruit fly

by  /  6 March 2012

The characteristics, interactions and roles of autism-associated genes in the fruit flies’ brain will help guide how we think about the same genes in humans, says Ralph Greenspan.

February 2012

Study charts methylation patterns in developing brain

by  /  22 February 2012

Researchers have charted patterns of DNA methylation — a chemical alteration to DNA that modifies gene expression — in the planning center of the brain from before birth to old age. The results were published 10 February in The American Journal of Human Genetics.


Human neuron model tests function of autism-linked genes

by  /  16 February 2012

Simulating neuronal development in culture with cells derived from human brain tissue offers a new way to study the function of autism-linked genes, according to research published in the February issue of Molecular Psychiatry.