Tag: neurexin

May 2012
News

Genetics: Mutations at neuronal junctions linked to autism

by  /  22 May 2012

Researchers have identified four new mutations in the autism-linked gene neurexin-1 in individuals who have autism and severe intellectual disability, they reported 3 April in Neurobiology of Disease.

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News

Genetics: Study further implicates rare CNVs in autism

by  /  2 May 2012

Individuals with autism are more likely than controls to have small, rare duplications or deletions of stretches of DNA in genes that play a role in dampening signals in the brain, according to a study published 2 April in Molecular Autism.

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April 2012
Opinion

Why oh Y

by  /  24 April 2012

New research on children with extra sex chromosomes points to the Y chromosome’s role in autism.

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March 2012
News / Toolbox

Autism mutations lead to scores of symptoms in rodents

by  /  14 March 2012

Mutations in more than 100 autism-associated genes lead to shared neurobiological deficits in mice, including alterations in the shape of their brains and changes to the electrical properties of neurons, according to a study published 20 February in Molecular Autism.

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News

Genetics: Autism linked to two mutations in same gene

by  /  14 March 2012

Two mutations in an autism-associated gene, neurexin-1, may have combined to cause autism in one man, whereas family members with only one of the two mutations have other neurological disorders, according to a study published 15 February in the American Journal of Medical Genetics Part B.

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News

Molecular mechanisms: Autism protein forms aggregates

by  /  13 March 2012

DISC1, an autism-associated protein, can form large aggregates that deplete the amount of functional DISC1 in cells, according to a study published 14 February in Human Molecular Genetics.

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Opinion / Viewpoint

Looking at autism through the fruit fly

by  /  6 March 2012

The characteristics, interactions and roles of autism-associated genes in the fruit flies’ brain will help guide how we think about the same genes in humans, says Ralph Greenspan.

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February 2012
News / Toolbox

Study charts methylation patterns in developing brain

by  /  22 February 2012

Researchers have charted patterns of DNA methylation — a chemical alteration to DNA that modifies gene expression — in the planning center of the brain from before birth to old age. The results were published 10 February in The American Journal of Human Genetics.

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News

Human neuron model tests function of autism-linked genes

by  /  16 February 2012

Simulating neuronal development in culture with cells derived from human brain tissue offers a new way to study the function of autism-linked genes, according to research published in the February issue of Molecular Psychiatry.

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January 2012
News

Molecular mechanisms: DISC1 variants inhibit neurogenesis

by  /  13 January 2012

Three variants of DISC1, a gene implicated in schizophrenia and autism, may disrupt the formation of new neurons in the brain, according to a study published 17 November in Neuron.

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