Tag: neurexin

November 2013

Compendium of mouse brains highlights autism’s diversity

by  /  14 November 2013

By mapping the brains of not 1 but 27 mouse models of autism, researchers are making sense of the widely divergent structural changes seen in autism brains, they reported Wednesday at the 2013 Society for Neuroscience annual meeting in San Diego.

Opinion / Viewpoint

SHANK mutations converge at neuronal junctions in autism

by ,  /  5 November 2013

SHANK3, one of the strongest candidate genes for autism, has the potential to be a molecular entry point into understanding the synaptic, developmental and circuit origins of the disorder.

October 2013
Opinion / Viewpoint

Length matters: Disease implications for long genes

by  /  22 October 2013

A gene’s length may influence its expression, and this has implications for autism, which tends to be linked to particularly long genes, says Mark Zylka. 

1 Comment
August 2013
News / Toolbox

New genetic background elicits aggression in mouse model

by  /  21 August 2013

Mice lacking neurexin-1, an autism-linked protein that helps stabilize the junctions between neurons, are highly aggressive, according to a study published 28 June in PLoS One. These mice share a consistent genetic background, which may account for this being the first social deficit seen in mice lacking this protein. 

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May 2013

Clinical research: Neurexin-1 deletions add to autism risk

by  /  24 May 2013

Deletions in neurexin-1, a candidate gene for autism, may cause intellectual disability, speech delays, seizures, poor muscle tone and unusual facial features, according to two studies published in the past two months.


Twin study finds epigenetic imprint of autism traits

by  /  16 May 2013

Epigenetics, or the chemical markings on DNA that affect gene expression, plays a role in some cases of autism, according to a study of 50 identical twins published 23 April in Molecular Psychiatry.

February 2013
Opinion / Viewpoint

Risk factors

by ,  /  26 February 2013

To focus the search for environmental risk factors in autism, we should look for chemicals that influence the molecular pathways associated with candidate risk genes, say Pamela Lein and Marianna Stamou.

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January 2013

Molecular mechanisms: Neuroligin brackets neuronal junctions

by  /  15 January 2013

Neuroligin-2, an autism-linked protein, functions at both sides of neuronal junctions in fruit flies, according to a study published 7 November in The Journal of Neuroscience. The proteins have only been seen at the signal-receiving ends of these junctions in vertebrates.

December 2012

Molecular mechanisms: Autism genes regulate cell sensors

by  /  18 December 2012

Genes involved in neuropsychiatric disorders tend to be required for the formation of primary cilia — small tentacles on the cell surface that sense the external environment — according to a study published 3 October in PLoS One.

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November 2012

Scientists home in on autism candidate gene’s role in brain

by  /  26 November 2012

Four new studies of neuroligin-1 (NLGN1), a gene linked to autism, unravel its complex role in regulating the connections between neurons.