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Spectrum: Autism Research News

Tag: mouse models

November 2010

Mouse models gene-environment interactions in autism

by  /  15 November 2010

The gene-environment interactions that are thought to contribute to many cases of autism can now be explored in a mouse model, according to a poster presented Sunday at the Society for Neuroscience annual meeting in San Diego.


Deer mouse model suggests combination therapy for autism

by  /  14 November 2010

A combination approach may hold promise for treating repetitive motor behaviors, such as those seen in people with autism, according to research presented yesterday at the Society for Neuroscience annual meeting in San Diego.


Molecular mechanisms: Maternal infection linked to schizophrenia in mice

by  /  9 November 2010

Infection early in pregnancy is more harmful to the fetus than at later stages, triggering brain and behavioral changes in the offspring similar to those seen in people with schizophrenia, according to two mouse studies published in October. A third study suggests that exercise can mitigate some of these effects.

October 2010

Nature vs. nurture

by  /  29 October 2010

Mice with social behavior deficits reminiscent of autism are friendlier when raised alongside a highly social mouse strain.


Cognition and behavior: SHANK1 mutant mice do not model autism

by  /  25 October 2010

SHANK1 — a member of a family of proteins linked to autism — does not cause autism-like social deficits when mutated in mice, according to a study published online in September in Brain Research.


Williams syndrome mouse hones in on genetic culprits

by  /  15 October 2010

A mouse model of Williams syndrome pinpoints a genetic region associated with the social behavior seen in the disorder, and may also yield insights into autism, says researcher Uta Francke, professor emeritus of genetics at Stanford University.


Multi-gene deletion creates model for Angelman syndrome

by  /  7 October 2010

A new mouse model of Angelman syndrome that knocks out a large stretch of a key chromosome is clarifying some of the molecular mechanisms underlying the more severe forms of the disorder.


Molecular mechanisms: Autism mutation causes neuroligin to misfold

by  /  6 October 2010

A point mutation in the autism-linked protein neuroligin-3 (NLGN3), seen in individuals with autism, causes the protein to misfold and localize to the wrong site in the cell, according to a study published in September in the Journal of Biological Chemistry.


Estrogen reverses autism-like features in mice

by  /  4 October 2010

Two new studies provide clues that may explain sex differences in autism prevalence. Italian researchers have found that injecting estrogen into the brains of young male mice reverses some of the structural and behavioral changes associated with low levels of reelin — a brain protein that has been previously implicated in autism — and the effects endure into adulthood.

August 2010

Studies explore amygdala problems in fragile X syndrome

by  /  31 August 2010

The amygdala, a brain region that regulates fear and anxiety, shows abnormal neuronal signaling in a mouse model of fragile X syndrome, according to two studies published this summer. These are the first to explore cellular defects in the region in fragile X.