Mice that lack the gene for integrin β3, or ITGB3 — which regulates the levels of serotonin in the blood — groom themselves frequently and show less interest in stranger mice compared with controls, according to a study published in February in Autism Research as part of a special issue on mouse models in autism.
Spectrum: Autism Research News
Tag: mouse models
Six strains of mice lacking a gene associated with fragile X syndrome show radically different behaviors though they share the same mutation, researchers reported in January in Autism Research.
A partial mutation that leads to a milder form of fragile X syndrome causes deficits in learning and memory in mice, and alters the connections between their neurons, according to a study published in January in Neurobiology of Disease.
Mice exposed to an epilepsy drug show several features of autism, including abnormal social interactions, repetitive behaviors and patterns of super-fast brain waves, called gamma oscillations, according to a study published 15 December in Biological Psychiatry.
Copy number variations, or CNVs — duplications or deletions of DNA segments — can influence the expression of unrelated genes on the same chromosome, according to a study published in November in PLOS Biology.
Scientists have created mice that carry mutations in SHANK3, one of the strongest candidate genes for autism. The animals have behavioral and neurobiological features reminiscent of autism, researchers reported 17 December in Molecular Autism.
Mice lacking one copy of a gene associated with Williams syndrome share the hyper-sociability of people with the disorder, according to a paper published online 3 December in Autism Research.
A new technique called array tomography allows researchers to visualize individual synapses, the complex junctions between neurons, in the mouse brain. Researchers have also identified several markers that highlight the incredible diversity of synapse types.