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Spectrum: Autism Research News

Tag: mouse models

November 2010

Tuberous sclerosis mice have fewer synaptic proteins

by  /  17 November 2010

A study of mice with tuberous sclerosis — a single-gene disorder that is related to autism — suggests that most forms of autism share a common feature: an imbalance of proteins at the synapse, the junction between neurons. The work was presented Monday at the Society for Neuroscience annual meeting in San Diego.

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Video: Of mice and men

by  /  16 November 2010

If you give most mice a choice between sniffing a new playmate and a new object, most will choose the new playmate every time. But not BTBR or SHANK3 mutant mice, which spend less time engaging in social interactions with other mice. Does that mean these mice have autism?

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Stem cell assay reveals early development of Rett neurons

by  /  16 November 2010

Researchers have developed the first stem cell system that makes it possible to study the early development of neurons from people with Rett syndrome, a rare disorder on the autism spectrum.

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Molecular mechanisms: Angelman gene linked to synapse formation

by  /  16 November 2010

UBE3A, a protein mutated in Angelman syndrome and autism, regulates communication between neurons in the brain, according to a study published 29 October in Cell.

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Mouse model of Timothy syndrome shows social deficits

by  /  15 November 2010

Mice bearing the genetic defect that causes Timothy syndrome show many autism-like behaviors, and may also have enhanced cognitive abilities like those seen in a small number of people with autism, suggests a poster presented Sunday at the Society for Neuroscience annual meeting in San Diego.

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Video: Unusual animals lead to interesting results

by  /  15 November 2010

A variety of animal models can help researchers better address human-specific questions in neurological disorders such as autism, says Theresa Lee, who has used exotic animal models to study circadian rhythms.

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Mouse models gene-environment interactions in autism

by  /  15 November 2010

The gene-environment interactions that are thought to contribute to many cases of autism can now be explored in a mouse model, according to a poster presented Sunday at the Society for Neuroscience annual meeting in San Diego.

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Deer mouse model suggests combination therapy for autism

by  /  14 November 2010

A combination approach may hold promise for treating repetitive motor behaviors, such as those seen in people with autism, according to research presented yesterday at the Society for Neuroscience annual meeting in San Diego.

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Molecular mechanisms: Maternal infection linked to schizophrenia in mice

by  /  9 November 2010

Infection early in pregnancy is more harmful to the fetus than at later stages, triggering brain and behavioral changes in the offspring similar to those seen in people with schizophrenia, according to two mouse studies published in October. A third study suggests that exercise can mitigate some of these effects.

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October 2010

Nature vs. nurture

by  /  29 October 2010

Mice with social behavior deficits reminiscent of autism are friendlier when raised alongside a highly social mouse strain.

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