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Spectrum: Autism Research News

Tag: mouse models

October 2011

Researchers debut mice with links to Williams syndrome

by  /  17 October 2011

Mouse pups with a duplication of GTF2I, a gene linked to Williams syndrome and autism, show extreme separation anxiety when separated from their mothers, according to unpublished findings presented Thursday at the International Congress of Human Genetics in Montreal, Canada.


Easy-to-make solution turns brains transparent

by  /  12 October 2011

Three common laboratory chemicals are all scientists need to create see-through brains ideal for visualizing complex neural circuits.


Two new autism mouse models highlight gene dosage effects

by  /  6 October 2011

Two new genetic mouse models that debuted this week show that having too many or too few copies of certain genetic regions leads to an array of symptoms reminiscent of autism.


Researchers engineer light-responsive strains of mice

by  /  5 October 2011

Researchers have engineered four new mouse lines that each show activation of a different subset of neurons in response to a blue light.


New mouse model mimics many symptoms of autism

by  /  3 October 2011

Mice lacking the autism-linked gene CNTNAP2 show many of the behaviors associated with the disorder, and exhibit brain circuit disruptions similar to those seen in people who carry mutations in the gene.

September 2011

Molecular mechanisms: Maternal stress affects male mice

by  /  30 September 2011

The male offspring of mice subjected to stress during pregnancy can transmit the effects to their own male pups.


Cognition and behavior: Mutant mice show social deficits

by  /  28 September 2011

Mice lacking a gene that regulates an important signaling pathway in the central nervous system have severe autism-like social deficits, including little interest in nurturing their offspring and problems with learning and memory.


Brain activity triggers widespread epigenetic changes

by  /  26 September 2011

Methylation marks were thought to be permanent features of the genome, but a new study challenges that idea.


Model systems

by  /  23 September 2011

The more we find out about human genetics, the more valuable model organisms are likely to become, say autism researchers.  


Molecular mechanisms: Fragile X brains have altered synapses

by  /  21 September 2011

Neurons in a mouse model of fragile X syndrome make more connections during a critical period in development compared with controls, but are slower to respond to signals.