Mice lacking the autism risk gene SHANK2 show social deficits and are extremely hyperactive, according to unpublished research presented Saturday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.
Spectrum: Autism Research News
Tag: mouse models
Deleting the Rett syndrome gene in a subset of neurons, instead of throughout the body, dramatically lowers the number of genes that are dysregulated in those neurons, according to results presented in a poster session Saturday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.
Wenbao Gan describes the technique he has devised to track the development of neurons in live mouse brains.
After analyzing the brains and behaviors of mutant mice and screening genes in people with autism, researchers have pinpointed what they say is a new autism candidate gene: PRICKLE2. The unpublished work was presented Thursday in Washington, D.C.
A drug in trials for treating autism-related disorders can reverse memory problems and anxiety in adult mice lacking the schizophrenia gene DISC1 in some cells. The unpublished results were presented yesterday in Washington, D.C.
The Rett syndrome gene MeCP2 may subtly regulate the expression of genes across the genome by altering DNA structure.
Researchers have sequenced 17 laboratory mice and mapped 56.7 million single-base DNA variants in their genomes, according to a study published 15 September in Nature. A companion paper in the same issue identifies more than 700,000 structural variants, which are insertions, deletions or other modifications of DNA.
A well-studied mouse model of autism has a smaller-than-normal volume in several autism-associated brain regions.
Mice lacking a copy of SHANK3, a gene associated with autism and intellectual disability, show marked improvements in brain signaling after being treated with insulin-like growth factor 1, according to unpublished findings presented Saturday at the International Congress of Human Genetics in Montreal, Canada.