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Spectrum: Autism Research News

Tag: mouse models

September 2011

Cognition and behavior: Fragile X treatment has ill effects

by  /  2 September 2011

A compound that shows promise as a treatment for fragile X syndrome alleviates repetitive behaviors in mice, but unexpectedly makes them less social.

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August 2011

How fish can help find causes of autism

by ,  /  29 August 2011

Zebrafish share genes and pathways with humans, making them a useful tool to identify the genes that malfunction in autism, says expert Hazel Sive.

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Molecular mechanisms: Antisocial mice have elevated immunity

by  /  26 August 2011

BTBR mice, which are less social than the typical B6 mice, have an elevated immune response in their brains and blood compared with those mice, according to a study published 20 July in PLoS ONE. Hybrids of BTBR and B6 mice have intermediate levels of immune molecules.

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Molecular mechanisms: MeCP2 regulated by chemical switch

by  /  17 August 2011

MeCP2, the protein missing in people with Rett syndrome, enhances learning and memory by binding to key genes and either activating or inhibiting their expression, according to a study published 17 July in Nature Neuroscience. Adding a phosphate to the protein in response to neuronal activity releases MeCP2 from these genes, the study found.

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Scientists aim to create scores of diverse mouse strains

by  /  17 August 2011

Researchers are creating a population of inbred lab mice with the potential to produce thousands of genetically diverse strains. Experiments using the first of these mice are published in the August issue of Genomic Research.

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Modified stem cells make glowing neurons

by  /  10 August 2011

A new technique allows researchers to make stable modifications to neurons by incorporating modified amino acids into the proteins of stem cells. The method permits researchers to investigate neuronal function in live, intact cells.

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Clinical research: Drug increases communication while rats play

by  /  5 August 2011

Giving GLYX-13, a drug that targets an autism-associated brain pathway, to rats bred to be less social increases how much they communicate while playing.

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July 2011

Fragile X protein found to regulate key autism candidates

by  /  28 July 2011

The protein missing in people with fragile X syndrome regulates the activity of more than 800 other proteins, including some key players in autism, according to a study published 22 July in Cell. Many of these autism-associated proteins cluster on either side of the synapse, the junction between neurons.

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Cognition and behavior: SHANK1 mutant mice keep quiet

by  /  26 July 2011

Mice lacking SHANK1, a member of a family of autism-associated proteins, communicate less with their mothers and potential mates than controls do, according to a study published 9 June in PLoS One.

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Ambitious venture aims to create a mouse for every gene

by  /  7 July 2011

A multi-site collaborative venture between the U.S., Canada and Europe has created nearly 17,000 mouse embryonic stem cell lines, each lacking one of the genes in the mouse genome.

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