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Spectrum: Autism Research News

Tag: mouse models

October 2011

Researchers engineer light-responsive strains of mice

by  /  5 October 2011

Researchers have engineered four new mouse lines that each show activation of a different subset of neurons in response to a blue light.


New mouse model mimics many symptoms of autism

by  /  3 October 2011

Mice lacking the autism-linked gene CNTNAP2 show many of the behaviors associated with the disorder, and exhibit brain circuit disruptions similar to those seen in people who carry mutations in the gene.

September 2011

Molecular mechanisms: Maternal stress affects male mice

by  /  30 September 2011

The male offspring of mice subjected to stress during pregnancy can transmit the effects to their own male pups.


Cognition and behavior: Mutant mice show social deficits

by  /  28 September 2011

Mice lacking a gene that regulates an important signaling pathway in the central nervous system have severe autism-like social deficits, including little interest in nurturing their offspring and problems with learning and memory.


Brain activity triggers widespread epigenetic changes

by  /  26 September 2011

Methylation marks were thought to be permanent features of the genome, but a new study challenges that idea.


Model systems

by  /  23 September 2011

The more we find out about human genetics, the more valuable model organisms are likely to become, say autism researchers.  


Molecular mechanisms: Fragile X brains have altered synapses

by  /  21 September 2011

Neurons in a mouse model of fragile X syndrome make more connections during a critical period in development compared with controls, but are slower to respond to signals.


Cognition and behavior: Probiotics alleviate anxiety in mice

by  /  20 September 2011

Probiotic bacteria alleviate stress in healthy mice and modify the expression of receptors for a chemical messenger that inhibits signaling in the brain.


Molecular mechanisms: Dopamine implicated in Rett syndrome

by  /  13 September 2011

Loss of MeCP2, the Rett syndrome gene, in neurons that release the chemical messenger dopamine may lead to the motor deficits associated with the syndrome.


First mouse model of Timothy syndrome debuts

by  /  5 September 2011

Researchers have created the first mouse model of Timothy syndrome, a rare genetic disorder that causes heart defects and autism. The findings appeared 30 August in the Proceedings of the National Academy of Sciences.