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Spectrum: Autism Research News

Tag: mouse models

October 2011

Researchers engineer light-responsive strains of mice

by  /  5 October 2011

Researchers have engineered four new mouse lines that each show activation of a different subset of neurons in response to a blue light.

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New mouse model mimics many symptoms of autism

by  /  3 October 2011

Mice lacking the autism-linked gene CNTNAP2 show many of the behaviors associated with the disorder, and exhibit brain circuit disruptions similar to those seen in people who carry mutations in the gene.

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September 2011

Molecular mechanisms: Maternal stress affects male mice

by  /  30 September 2011

The male offspring of mice subjected to stress during pregnancy can transmit the effects to their own male pups.

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Cognition and behavior: Mutant mice show social deficits

by  /  28 September 2011

Mice lacking a gene that regulates an important signaling pathway in the central nervous system have severe autism-like social deficits, including little interest in nurturing their offspring and problems with learning and memory.

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Brain activity triggers widespread epigenetic changes

by  /  26 September 2011

Methylation marks were thought to be permanent features of the genome, but a new study challenges that idea.

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Model systems

by  /  23 September 2011

The more we find out about human genetics, the more valuable model organisms are likely to become, say autism researchers.  

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Molecular mechanisms: Fragile X brains have altered synapses

by  /  21 September 2011

Neurons in a mouse model of fragile X syndrome make more connections during a critical period in development compared with controls, but are slower to respond to signals.

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Cognition and behavior: Probiotics alleviate anxiety in mice

by  /  20 September 2011

Probiotic bacteria alleviate stress in healthy mice and modify the expression of receptors for a chemical messenger that inhibits signaling in the brain.

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Molecular mechanisms: Dopamine implicated in Rett syndrome

by  /  13 September 2011

Loss of MeCP2, the Rett syndrome gene, in neurons that release the chemical messenger dopamine may lead to the motor deficits associated with the syndrome.

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First mouse model of Timothy syndrome debuts

by  /  5 September 2011

Researchers have created the first mouse model of Timothy syndrome, a rare genetic disorder that causes heart defects and autism. The findings appeared 30 August in the Proceedings of the National Academy of Sciences.

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