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Spectrum: Autism Research News

Tag: mouse models

November 2011

Rapamycin reverses memory deficits in DISC1-deficient mice

by  /  10 November 2011

A drug in trials for treating autism-related disorders can reverse memory problems and anxiety in adult mice lacking the schizophrenia gene DISC1 in some cells. The unpublished results were presented yesterday in Washington, D.C.

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Molecular mechanisms: MeCP2 may modify DNA structure

by  /  9 November 2011

The Rett syndrome gene MeCP2 may subtly regulate the expression of genes across the genome by altering DNA structure.

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Researchers map genetic variation in mice

by  /  9 November 2011

Researchers have sequenced 17 laboratory mice and mapped 56.7 million single-base DNA variants in their genomes, according to a study published 15 September in Nature. A companion paper in the same issue identifies more than 700,000 structural variants, which are insertions, deletions or other modifications of DNA.

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October 2011

Cognition and behavior: Mouse model has autism-like brain

by  /  28 October 2011

A well-studied mouse model of autism has a smaller-than-normal volume in several autism-associated brain regions.

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Mouse vs. mouse

by  /  21 October 2011

A new study describes a mutant mouse that, despite missing an autism-linked gene, doesn’t show any autism-like behaviors.

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Growth factor improves autism symptoms in mice

by  /  19 October 2011

Mice lacking a copy of SHANK3, a gene associated with autism and intellectual disability, show marked improvements in brain signaling after being treated with insulin-like growth factor 1, according to unpublished findings presented Saturday at the International Congress of Human Genetics in Montreal, Canada.

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Genetics: Mutant mice finger new gene in autism region

by  /  18 October 2011

Deleting one copy of TBX1, a gene located on the autism-linked chromosomal region 22q11.2, leads to social and communication deficits in mice.

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Researchers debut mice with links to Williams syndrome

by  /  17 October 2011

Mouse pups with a duplication of GTF2I, a gene linked to Williams syndrome and autism, show extreme separation anxiety when separated from their mothers, according to unpublished findings presented Thursday at the International Congress of Human Genetics in Montreal, Canada.

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Easy-to-make solution turns brains transparent

by  /  12 October 2011

Three common laboratory chemicals are all scientists need to create see-through brains ideal for visualizing complex neural circuits.

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Two new autism mouse models highlight gene dosage effects

by  /  6 October 2011

Two new genetic mouse models that debuted this week show that having too many or too few copies of certain genetic regions leads to an array of symptoms reminiscent of autism.

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