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Spectrum: Autism Research News

Tag: mouse models

November 2011

Mouse lines light up the brain’s off switch

by  /  16 November 2011

Researchers have engineered 20 mouse lines that allow them to manipulate genes in specific neuronal circuits. The resource, reported 22 September in Neuron, will allow researchers to better explore the role of interneurons, which dampen signals in the brain, in mouse models of autism. 

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Valproate rat model implicates adrenaline in autism

by  /  16 November 2011

Drugs that act on the adrenaline system can alleviate autism-like symptoms in a rat model of the disorder, according to unpublished research presented Sunday in Washington, D.C.

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Cognition and behavior: Rett syndrome mice are social

by  /  16 November 2011

Mice with a mutation in the Rett syndrome gene are more social than controls, according to a study published 11 September in Behavioral Genetics. The results, based on detailed observation of social behavior, support previous studies showing that Rett syndrome mouse models do not have severe social deficits.

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Video: From men to mice and back again

by  /  15 November 2011

In a video interview at the 2011 Society for Neuroscience annual meeting in Washington, D.C., Joseph Buxbaum discussed the importance of mice with mutations in SHANK3, a leading autism candidate gene.

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Mouse study points to potential therapy for fragile X syndrome

by  /  15 November 2011

A protein involved in the cascade of interactions at the junctions between neurons points to a potential therapy for fragile X syndrome, according to unpublished data presented at the 2011 Society for Neuroscience annual meeting in Washington, D.C.

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Different doses of Rett protein produce similar effects

by  /  15 November 2011

Mice that have an excess of the Rett syndrome protein MeCP2 have biochemical and neuronal characteristics that are strikingly similar to those of mice that completely lack the protein, according to unpublished research described Sunday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.

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Researchers debut SHANK2 mouse, SHANK3 rat

by  /  14 November 2011

Mice lacking the autism risk gene SHANK2 show social deficits and are extremely hyperactive, according to unpublished research presented Saturday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.

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Subset of Rett gene’s targets may lead to the disorder

by  /  14 November 2011

Deleting the Rett syndrome gene in a subset of neurons, instead of throughout the body, dramatically lowers the number of genes that are dysregulated in those neurons, according to results presented in a poster session Saturday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.

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Video: Microscopy follows neurons in live mouse brains

by  /  13 November 2011

Wenbao Gan describes the technique he has devised to track the development of neurons in live mouse brains.

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PRICKLE2 is new autism candidate gene, group says

by  /  10 November 2011

After analyzing the brains and behaviors of mutant mice and screening genes in people with autism, researchers have pinpointed what they say is a new autism candidate gene: PRICKLE2. The unpublished work was presented Thursday in Washington, D.C.

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