A new rat study shows that the precise timing of early valproate exposure, an autism risk factor, can have a big influence on behavior later in development.

Mice that are unable to produce a carbohydrate molecule that regulates cell growth show behaviors that resemble the core deficits of autism, according to a study published 27 March in the Proceedings of the National Academy of Sciences.

A robot can replace researchers in performing a painstaking technique that records neuronal signals in live animal brains, according to a study published 6 May in Nature Methods.

Researchers typically use only one ‘cohort,’ a group of about three dozen mice, for a given set of experiments. When others repeat the experiments with a different set of animals, sometimes the results hold up, and sometimes they don’t.

Long-term treatment with antipsychotic drugs and mood stabilizers can change the structure of the brain.

Mice lacking the autism-associated gene SHANK2 show autism-like behaviors similar to those seen in mice lacking SHANK3, another member of the same gene family. But SHANK2 and SHANK3 mice have distinct alterations at neuronal junctions, according to a report published 29 April in Nature.

Researchers have identified deletions in SHANK1 — the third member of a gene family that is closely linked to autism — in five men with the disorder, they reported 4 May in the American Journal of Human Genetics. This is the first study linking SHANK1 mutations to people with autism.

Researchers have created sponge-like assemblies of hundreds of thousands of short fragments of RNA, which can be used to dampen the expression of certain genes, according to a study published 26 February in Nature Materials.

A promising approach to treating fragile X syndrome could benefit people even after the critical window of early brain development, and alleviate core symptoms of autism, according to two studies published this month.

Two studies report abnormalities in the system that mediates the body’s response to stress in two mouse models of autism-related diseases: Angelman syndrome and Rett syndrome. The results were published in the April issue of Human Molecular Genetics.