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Tag: mitochondria

December 2013

Molecular mechanisms: Rett gene boosts protein production

by  /  3 December 2013

MeCP2, the protein mutated in Rett syndrome, is normally responsible for boosting the expression of a large number of genes. This finding, published 3 October in Cell Stem Cell, may explain why growth factors that promote protein production are able to reverse features of the syndrome in mice.

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April 2013

Drug linked to mitochondria treats mouse model of autism

by  /  15 April 2013

A century-old drug created to treat African sleeping sickness reverses several autism-like features in a mouse model of the disorder, according to a study published 13 March in PLoS ONE.

January 2013
News / Toolbox

Fluorescent fish help track mitochondrial motion

by  /  16 January 2013

Fish engineered to express fluorescent proteins allow researchers to follow the paths of migrating mitochondria, the cell’s energy producers, according to a study published 14 November in The Journal of Neuroscience.

Opinion / Viewpoint

Exploring enigmatic links between mitochondria and autism

by  /  8 January 2013

Mitochondrial deficits may account for the range of symptoms and neurological deficits seen in autism and explain why it preferentially affects boys, says Douglas Wallace.

November 2012

Molecular mechanisms: Gene expression differs in autism

by  /  20 November 2012

The brains of individuals with autism express low levels of genes involved in metabolism and protein assembly, according to a postmortem study published 12 September in PLoS One.

October 2012
News / Profiles

Thomas Bourgeron: Pioneering rare paths in autism genetics

by  /  25 October 2012

Thomas Bourgeron discovered the first rare mutation linked to non-syndromic autism, pointing to neuronal connections as prime drug targets.


Mouse model links autism risk gene to mitochondria

by  /  11 October 2012

A new mouse model provides the first molecular link between the known autism risk gene PTEN and the mitochondrial dysfunction sometimes seen in the disorder. Mice with half the normal amount of PTEN protein in their brains have social deficits reminiscent of autism and faulty mitochondria, according to a study published 10 August in PLoS One.

July 2012
News / Toolbox

Expression data links gene candidates to autism

by  /  11 July 2012

Identifying genetic variants that affect the expression of other genes can enhance traditional gene association analyses and highlight candidate risk factors for autism, according to a study published 16 May in Molecular Autism.

May 2012

Defects in carnitine metabolism may underlie autism

by  /  10 May 2012

A genetic defect in the synthesis of carnitine, a molecule that is essential for proper mitochondrial function, might slightly increase risk for autism in some children, according to research published 8 May in the Proceedings of the National Academy of Sciences.

March 2012

Molecular mechanisms: Autism protein forms aggregates

by  /  13 March 2012

DISC1, an autism-associated protein, can form large aggregates that deplete the amount of functional DISC1 in cells, according to a study published 14 February in Human Molecular Genetics.