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Tag: mGluR5

March 2021
Hands of researcher in two colors, one hand with Fragile X and the other with COIVD shapes connected by multicolored dots.
Opinion / Q&A

Fragile X researcher takes on COVID-19

by  /  2 March 2021

Cara Westmark has spent the past year building the case that a drug designed for fragile X syndrome might help coronavirus patients, too.

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October 2020
Ralf Schmid, the research director in Neurodevelopmental diseases at the Gene Therapy Program Orphan Disease Center, loads replicated mouse dna into wells in the gel before applying electric current to test the viability of the dna.
Features / Deep Dive

A quest for Quincy: Gene therapies come of age for some forms of autism

by ,  /  14 October 2020

A gene therapy for Angelman syndrome stands at the forefront of efforts to treat autism-linked conditions that stem from single genes.

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October 2019
News

Mouse study hints at why fragile X drugs fail in trials

by  /  22 October 2019

Drug after drug has failed in clinical trials for fragile X syndrome. A new study provides an explanation — a decrease in the drugs’ effectiveness over time — and points to a new strategy that could circumvent this problem.

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October 2018
Illustration of research mice forming the letter 'X'.
News

Fragile X syndrome’s link to autism, explained

by  /  10 October 2018

Fragile X syndrome is a leading genetic cause of autism. People who have either condition often share certain traits, such as difficulties in social situations.

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September 2018
Drawing shows scientists moving in different directions in a matrix of molecules and and genetic material.
News

Newly discovered aspects of fragile X spur next wave of drugs

by  /  24 September 2018

Many drugs for fragile X syndrome have failed in large clinical trials, but candidates that target new aspects of the condition may fare better.

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June 2018
Week of JuneJun
25th
2018
News / Spotted

Smart genes; Neanderthal mini-brains; diabetes link and more

by  /  29 June 2018

Autism and intelligence share genetic variants, researchers grow Neanderthal mini-brains and see overlap with autism, and maternal diabetes is an autism risk factor.

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May 2018
Microscopic image of skin cells
News

Study challenges theory that protein surplus underlies fragile X

by  /  16 May 2018

Many people with fragile X syndrome show average rates of protein production, challenging a long-held assumption about the condition.

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November 2017
Mapping the connections between brain regions in mice can reveal which ones are strengthened by a drug.
News

Mouse imaging study hints at how fragile X drug trial went wrong

by  /  15 November 2017

The drug mavoglurant has no effect on a brain circuit involved in social behavior in a mouse model of fragile X syndrome. That may explain its poor performance in people with the condition.

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lab mouse in scientists hand with blue gloves
News

Selective enzyme block reveals new treatment for fragile X

by  /  14 November 2017

A drug that selectively blocks one form of an enzyme called GSK-3 prevents seizures and improves cognitive deficits in a mouse model of fragile X syndrome.

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February 2017
Several arrows have fallen short of their target, which is a pill on a bullseye. This image suggests that a drug targeted towards autism's symptoms has not yet been made.
Features / Deep Dive

Why don’t we have better drugs for autism?

by  /  15 February 2017

Clinical trials for autism drugs have been plagued with problems: bad design, the wrong measures, too broad a range of participants. All that is finally starting to change.

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