Tag: mGluR5

October 2018
Illustration of research mice forming the letter "X".
News

Fragile X syndrome’s link to autism, explained

by  /  10 October 2018

Fragile X syndrome is a leading genetic cause of autism. People who have either condition often share certain traits, such as difficulties in social situations.

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September 2018
Drawing shows scientists moving in different directions in a matrix of molecules and and genetic material.
News

Newly discovered aspects of fragile X spur next wave of drugs

by  /  24 September 2018

Many drugs for fragile X syndrome have failed in large clinical trials, but candidates that target new aspects of the condition may fare better.

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June 2018
Week of JuneJun
25th
2018
News / Spotted

Smart genes; Neanderthal mini-brains; diabetes link and more

by  /  29 June 2018

Autism and intelligence share genetic variants, researchers grow Neanderthal mini-brains and see overlap with autism, and maternal diabetes is an autism risk factor.

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May 2018
Microscopic image of skin cells
News

Study challenges theory that protein surplus underlies fragile X

by  /  16 May 2018

Many people with fragile X syndrome show average rates of protein production, challenging a long-held assumption about the condition.

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November 2017
Mapping the connections between brain regions in mice can reveal which ones are strengthened by a drug.
News

Mouse imaging study hints at how fragile X drug trial went wrong

by  /  15 November 2017

The drug mavoglurant has no effect on a brain circuit involved in social behavior in a mouse model of fragile X syndrome. That may explain its poor performance in people with the condition.

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lab mouse in scientists hand with blue gloves
News

Selective enzyme block reveals new treatment for fragile X

by  /  14 November 2017

A drug that selectively blocks one form of an enzyme called GSK-3 prevents seizures and improves cognitive deficits in a mouse model of fragile X syndrome.

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February 2017
Features / Deep Dive

Why don’t we have better drugs for autism?

by  /  15 February 2017

Clinical trials for autism drugs have been plagued with problems: bad design, the wrong measures, too broad a range of participants. All that is finally starting to change.

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November 2016
News

Despite setbacks, fragile X drugs file into clinical trials

by  /  30 November 2016

Our infographic displays efforts to develop treatments for fragile X syndrome. So far, none of them have passed muster in clinical trials.

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February 2016
Multimedia / Webinars

Webinar: Sébastien Jacquemont on gene variants’ ties to autism

24 February 2016

Watch the complete replay of Sébastien Jacquemont discussing cognitive, behavioral and neural changes underlying the link between genes and conditions such as autism.

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January 2016
Week of JanuaryJan
11th
2016
News / Spotted

CRISPR chronicles; microbiome muddle; love on the spectrum

by  /  15 January 2016

The fight over who holds the rights to CRISPR is heating up, we control our gut bacteria, and romance isn’t always easy when you have autism.

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