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Tag: MECP2

March 2017
News

Muting X chromosome silencers may serve as remedy for Rett

by  /  30 March 2017

Manipulating pathways that help silence the X chromosome may help treat Rett syndrome, a condition closely related to autism.

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Four white mice bike ahead of a white rat, who is juggling on a unicycle; suggesting that rats can do more for research than mice.
Features / Deep Dive

Meet the newest contestant in the scientific rat race

by  /  15 March 2017

Mice have long been the mainstay of autism research, but a small group of scientists say rats are the superior choice. Rats are bigger, smarter, friendlier — and a lot more fun.

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Opinion / Viewpoint

Questions for Huda Zoghbi: Studying Rett in the rodent brain

by  /  14 March 2017

Removing the Rett syndrome gene, MeCP2, from distinct cells and brain regions reveals hidden features of the condition.

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illustration of person with autism struggling with addiction
Features / Deep Dive

Autism’s hidden habit

by  /  1 March 2017

Conventional wisdom holds that people with autism don’t get hooked on alcohol or other drugs, but new evidence suggests otherwise.

4 Comments
January 2017
News

Sound processing skewed in mouse model of Rett syndrome

by  /  27 January 2017

Researchers have traced an unusual maternal behavior in female mice modeling Rett syndrome to a neural circuit that processes sound. They have also found a drug that reverses this behavior.

3 Comments
December 2016
Features / Special Reports / 2016: Year in review

Notable papers of 2016

26 December 2016

Our picks for the top 10 papers of the year highlight leaps in our understanding of autism, as well as lingering gaps.

1 Comment
November 2016
News

Extra dose of Rett syndrome gene alters brain waves in monkeys

by  /  16 November 2016

Monkeys with multiple copies of the gene MeCP2 have irregular brain waves similar to those seen in some children with autism.

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News

New treatment for Rett syndrome targets cerebrospinal fluid

by  /  15 November 2016

Lowering the levels of OTX2, a protein found in the fluid that bathes the brain, prevents many abnormal behaviors in mouse models of Rett syndrome.

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September 2016
News

Brain’s immune cells may only play bit part in Rett syndrome

by  /  21 September 2016

Contrary to some previous reports, microglia may not play a central role in initiating Rett syndrome.

1 Comment
News

Loss, doubling of Rett gene produce similar brain glitch

by  /  15 September 2016

Mice with either too little or too much MeCP2, the gene mutated in Rett syndrome, show similar malfunctions in a learning and memory circuit.

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