Altering a protein linked to Rett syndrome so that it cannot bind to a methylation tag in neurons results in Rett-like traits in mice.

Female mice missing a copy of the autism-linked gene MECP2 in a specific set of inhibitory neurons have a hard time heeding pups’ calls and herding litters.

Treatments for Rett syndrome that aim to boost levels of the protein MECP2 may not help everyone with the condition.

Mutations in the MECP2 gene, which are associated with autism and Rett syndrome, interfere with a cell’s ability to form droplets of DNA that silence gene expression.

An experimental drug tamps down the expression of a gene duplicated in an autism-related condition and restores typical behavior in mice.

Researchers have used the gene-editing tool CRISPR to disable the MECP2 gene in marmoset embryos. The six such marmosets created seem to recapitulate aspects of Rett syndrome.

Studies of Rett syndrome hint at genes, cells and brain circuits that may be involved in autism — and may pave the way to treatments for both conditions.

Heart-rate patterns and changes in pupil size may herald Rett syndrome, autism or related conditions.

An experimental leukemia drug and a chemical in black pepper ease breathing and movement problems in a mouse model of Rett syndrome.

Problems with protein-filled parcels called exosomes may contribute to Rett syndrome, a condition related to autism.