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Tag: MECP2

April 2010
News

Rett gene found to control genome structure in neurons

by  /  9 April 2010

The protein that is mutated in Rett syndrome controls the expression of other genes by changing the way DNA packs into a cell, rather than turning genes on or off, according to a study published in Molecular Cell.

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November 2009
News

MeCP2 loss leads to smaller neurons in brain region

by  /  18 November 2009

Deleting MeCP2, the gene that’s mutated in Rett syndrome, alters both the size and function of neurons in the mouse brain — at least in one brain region, the locus ceruleus — according to a 30 September report in the Journal of Neuroscience.

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News

Autism marked by altered trajectory of brain growth

by  /  3 November 2009

Although the head overall is bigger in some children with autism, researchers have found more informative differences in size — some smaller, some larger — across regions of the brain.

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October 2009
News

Enriched environment improves symptoms of Rett

by  /  23 October 2009

Giving mouse models of Rett syndrome access to toys, wheels and contact with other mice rescues motor skill and other deficits characteristic of the disorder, according to results presented in a poster session Wednesday at the Society for Neuroscience meeting in Chicago.

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News

MeCP2 loss ups inhibitory signaling

by  /  21 October 2009

Selectively disrupting an autism-related gene in cultured human neurons causes a dramatic imbalance of excitation and inhibition in cell signaling, according to unpublished results presented today at the Society for Neuroscience meeting in Chicago.

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June 2009
News

Study links autism to stem cell development

by  /  23 June 2009

The molecular defects that cause some cases of autism may arise during the development of neuronal stem cells, according to a new theory bolstered by several independent animal and human studies.

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November 2008
News

Treating Rett syndrome

by  /  17 November 2008

Treatment with the insulin-like growth factor (IGF) greatly improves the health of mouse models of Rett syndrome ― a regressive genetic disorder that causes mental retardation, seizures, and autistic features ― according to unpublished researched presented this morning at the Society for Neuroscience conference.

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January 2008
Opinion / Viewpoint

The 1999 Rett syndrome paper

by  /  3 January 2008

Huda Zoghbi and her colleagues painstakingly sequenced the candidate genes for Rett syndrome, culminating in the 1999 Nature Genetics report that pinpointed six de novo mutations in the MeCP2 gene as the cause of the disorder.

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News / Profiles

Josh Huang: In dogged pursuit of autism’s off switch

by  /  3 January 2008

In 1982, Josh Huang was an impressionable young biology undergraduate at Shanghaiʼs FuDan University. Like some of his fellow Chinese students, he knew he wanted to be a neuroscientist, but with limited access to scientific journals, had no idea which big questions were then at the forefront of research.

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