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Spectrum: Autism Research News

Tag: MECP2

September 2022
Set of 6 scans shows mice recovering MECP2 protein in their brainstem after being treated with RNA-editing viruses.

RNA rewrite improves breathing, survival in Rett mice

by  /  22 September 2022

The technique involves editing the cellular instructions to make MECP2 protein and partially restores its levels in the brainstem.

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July 2022
Illustration shows calcium signaling astrocytes, which are star-shaped and change color from light blue to purple.

Portrait of a research field: astrocytes in autism

by  /  14 July 2022

Long cast in supporting roles in the brain, astrocytes are now emerging as primary players in certain characteristics of autism and related conditions.

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April 2022

Faulty inhibition foils long-term memory in Rett mice

by  /  11 April 2022

The animals recall fear more readily if a set of inhibitory neurons in the hippocampus is switched on.

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March 2022
A family of Macaques aat the Yerkes National Primate Research Center Field Station, Lawrenceville, Georgia.

Macaques’ social skills tied to variation in autism-linked genes

by  /  7 March 2022

Genetics strongly influences some aspects of the monkey’s social behavior, including tendencies to solicit grooming and sit or play alone.

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Silenced X chromosome genes reawaken in new mouse model

by  /  3 March 2022

The new animal line could accelerate the discovery of gene-activating therapies for the autism-linked condition Rett syndrome.

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February 2022
Micrograph of neurons with excess neurons due to excess MECP2 expression.

Protein complex points to new route to Rett syndrome

by  /  18 February 2022

Mutations in a newly identified protein complex that interacts with the Rett protein also lead to a Rett-like condition in mice, researchers say.

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Real-world data on Rett syndrome: Q&A with Jana von Hehn

by  /  8 February 2022

The Rett Syndrome Global Registry is gathering data from people around the world with the rare condition to support clinical trials.

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Dr. Hollis Cline at her desk.

Hollis Cline: Leapfrogging over gaps in autism research

by  /  1 February 2022

A basic scientist at heart, Hollis Cline has spent decades pushing the boundaries of what researchers can see in the brain. Her persistence has led to a deeper understanding of how some autism-linked genes influence brain development.

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January 2022

Growth factor analogue shows promise for Rett syndrome in late-stage trial

by  /  25 January 2022

Girls and young women with Rett syndrome have less severe anxiety and breathing problems after treatment with trofinetide, an analogue of insulin-like growth factor 1, according to an unpublished placebo-controlled trial.

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November 2021

Gene therapy for rare form of autism may treat another

by  /  11 November 2021

A MECP2 gene therapy for Rett syndrome eases repetitive behaviors, anxiety and hyperactivity in a mouse model of Pitt-Hopkins syndrome.

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