The technique involves editing the cellular instructions to make MECP2 protein and partially restores its levels in the brainstem.
Spectrum: Autism Research News
Long cast in supporting roles in the brain, astrocytes are now emerging as primary players in certain characteristics of autism and related conditions.
The animals recall fear more readily if a set of inhibitory neurons in the hippocampus is switched on.
Genetics strongly influences some aspects of the monkey’s social behavior, including tendencies to solicit grooming and sit or play alone.
The new animal line could accelerate the discovery of gene-activating therapies for the autism-linked condition Rett syndrome.
Mutations in a newly identified protein complex that interacts with the Rett protein also lead to a Rett-like condition in mice, researchers say.
The Rett Syndrome Global Registry is gathering data from people around the world with the rare condition to support clinical trials.
A basic scientist at heart, Hollis Cline has spent decades pushing the boundaries of what researchers can see in the brain. Her persistence has led to a deeper understanding of how some autism-linked genes influence brain development.
Girls and young women with Rett syndrome have less severe anxiety and breathing problems after treatment with trofinetide, an analogue of insulin-like growth factor 1, according to an unpublished placebo-controlled trial.
A MECP2 gene therapy for Rett syndrome eases repetitive behaviors, anxiety and hyperactivity in a mouse model of Pitt-Hopkins syndrome.