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Spectrum: Autism Research News

Tag: MECP2

November 2021

Gene therapy for rare form of autism may treat another

by  /  11 November 2021

A MECP2 gene therapy for Rett syndrome eases repetitive behaviors, anxiety and hyperactivity in a mouse model of Pitt-Hopkins syndrome.

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Dispatches from SfN 2021: Mitochondria, Rett therapy and oxytocin

These short reports from Spectrum journalists highlight some of the autism-related findings that caught our attention at the meeting this past week.

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July 2021
Micrographs comparing motor cortex neurons in mice with and without an extra copy of MECP2 gene.

Blocking key pathway reverses brain, behavior changes in autism mouse model

by  /  19 July 2021

Neurons in mice with an autism-linked mutation sprout extraneous protrusions, an overgrowth accompanied by above-average motor learning. Inhibiting a cell signaling pathway reverses the effect.

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June 2021
Dr. Huda Zoghbi portrait

Huda Zoghbi: Taking genetic inquiry to the next level

by  /  25 June 2021

Over the course of a career spanning more than three decades, Huda Zoghbi has won almost every major biology and neuroscience research award that exists. More than 20 years since she discovered the gene behind Rett syndrome, she remains laser focused on unlocking the condition’s secrets and finding effective treatments.

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lab technician pipetting in dramatic light

Alternative gene-therapy approaches take aim at Rett syndrome

by  /  16 June 2021

Methods that selectively increase levels of the Rett protein make for safer and more effective treatment strategies, some researchers say.

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March 2021
Mouse brain neurons labeled with a genetic marker show pink on a dramatic blue background.

Early training forestalls motor, memory difficulties in mouse model of Rett syndrome

by  /  24 March 2021

Motor and memory training early in life postpones the onset of difficulties in those areas in a mouse model of Rett syndrome, and stimulating neurons involved in those skills appears to mimic the effects of training.

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Broken protein bridge linked to Rett syndrome traits

by  /  1 March 2021

Altering a protein linked to Rett syndrome so that it cannot bind to a methylation tag in neurons results in Rett-like traits in mice.

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January 2021
Mouse with her pup

Malfunctioning neurons mute sound processing in mouse model of Rett syndrome

by  /  14 January 2021

Female mice missing a copy of the autism-linked gene MECP2 in a specific set of inhibitory neurons have a hard time heeding pups’ calls and herding litters.

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Two mice in a rotarod machine

Mouse study sounds note of caution for Rett syndrome therapies

by  /  13 January 2021

Treatments for Rett syndrome that aim to boost levels of the protein MECP2 may not help everyone with the condition.

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August 2020
Series of micrographs showing neurons with Rett syndrome mutations lacking liquid compartments around DNA.

DNA droplets may be key to Rett syndrome, researchers say

by  /  27 August 2020

Mutations in the MECP2 gene, which are associated with autism and Rett syndrome, interfere with a cell’s ability to form droplets of DNA that silence gene expression.

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