Neuronal alterations outside the brain may help to explain a host of the condition’s characteristic traits, including sensory changes, gut problems and motor differences.
Spectrum: Autism Research News
The drug, welcomed by patients, might be just the first of many.
The technique involves editing the cellular instructions to make MECP2 protein and partially restores its levels in the brainstem.
Long cast in supporting roles in the brain, astrocytes are now emerging as primary players in certain characteristics of autism and related conditions.
The animals recall fear more readily if a set of inhibitory neurons in the hippocampus is switched on.
Genetics strongly influences some aspects of the monkey’s social behavior, including tendencies to solicit grooming and sit or play alone.
The new animal line could accelerate the discovery of gene-activating therapies for the autism-linked condition Rett syndrome.