Tag: macrocephaly

March 2013
News

Genetics: Head size heterogeneous in autism

by  /  6 March 2013

Children who have autism and large heads may belong to different clinical subsets based on the ratio between their head size and height, according to a study published in the February issue of Autism Research.

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February 2013
News

Twin study suggests large head size runs in autism families

by  /  14 February 2013

Children with autism and their unaffected twins have heads that are significantly larger than average, according to a study published 16 January in the Journal of Autism and Developmental Disorders.

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News / Toolbox

Researchers carve out map of rodent brain

by  /  13 February 2013

Researchers have divided the rat brain into 26 structures that are present from birth to adulthood and that can be seen using brain imaging, according to a study published 15 February in Neuroimage.

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December 2012
News

Clinical research: Larger brains in autism, fragile X

by  /  19 December 2012

Young boys with fragile X syndrome or autism have larger brains overall than controls do, but the two groups show enlargement of different parts of the brain, according to an imaging study published in September in the Journal of the American Academy of Child and Adolescent Psychiatry.

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November 2012
News

Genetics: Deletion of 16p11.2 region has variable effects

by  /  14 November 2012

The loss of a 600-kilobase region on chromosome 16 leads to intellectual disability, obesity, a large head and, sometimes, autism, according to a study published in the October issue of the Journal of Medical Genetics.

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October 2012
News

Molecular mechanisms: Immune molecule boosts brain size

by  /  23 October 2012

Mice with elevated levels of the immune molecule interleukin-6 have abnormally large brains, according to a study published 23 August in the International Journal of Neuroscience.

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News

Mouse model links autism risk gene to mitochondria

by  /  11 October 2012

A new mouse model provides the first molecular link between the known autism risk gene PTEN and the mitochondrial dysfunction sometimes seen in the disorder. Mice with half the normal amount of PTEN protein in their brains have social deficits reminiscent of autism and faulty mitochondria, according to a study published 10 August in PLoS One.

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July 2012
News

Maternal antibodies may affect brain size in autism

by  /  12 July 2012

The action of certain maternal antibodies on the fetal brain may underlie the large brain size seen in some children with autism, according to preliminary findings from both monkey and human studies presented at a conference in Boston last week.

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June 2012
News

Genetics: Deletions in neurexin-1 linked to seizures

by  /  27 June 2012

Deletions in the second half of the autism-linked gene neurexin-1 are associated with seizures and large head size, according to a study published 23 May in the European Journal of Human Genetics.

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May 2012
News

Autism gene PTEN plays vital role in neural stem cells

by  /  31 May 2012

Knocking out an autism-linked gene called PTEN only in neural stem cells of the hippocampus, a brain region central to learning and memory, throws the development of new neurons off course in adult mice, according to research published last month in the Journal of Neuroscience.

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