Six strains of mice lacking a gene associated with fragile X syndrome show radically different behaviors though they share the same mutation, researchers reported in January in Autism Research.

A partial mutation that leads to a milder form of fragile X syndrome causes deficits in learning and memory in mice, and alters the connections between their neurons, according to a study published in January in Neurobiology of Disease.

Men with fragile X syndrome have larger brains overall than controls do, but less matter in regions involved in language and social interaction.

A new intervention that teaches toddlers skills in a real-world environment — a playgroup rather than a one-on-one interaction with a researcher, for instance — more than doubles their ability to imitate others, according to a January study in The Journal of Child Psychology and Psychiatry.

Children with autism spend less time in the rapid eye movement stage of sleep than do either controls or those with developmental delays, according to a November report in the Archives of Pediatrics & Adolescent Medicine.

A new drug appears to relieve symptoms of fragile X syndrome by blocking the over-production of a key protein in a subset of people with the disorder, according to a 6 January study in Science Translational Medicine.

Computerized three-dimensional modeling shows nerve cell abnormalities in the hippocampus of fragile X mice — and suggests the importance of raising experimental mice in more natural habitats, according to a poster presented Wednesday at the Society for Neuroscience annual meeting in San Diego.

Lithium ameliorates some of the cognitive and behavioral deficits associated with fragile X syndrome by blocking GSK-3, an enzyme that plays a key role in development, researchers said Wednesday at the Society for Neuroscience annual meeting in San Diego.

The brains of young mice with fragile X syndrome show a dearth of two proteins that are important at the synapse, the junction between neurons, researchers reported Tuesday at the Society for Neuroscience annual meeting in San Diego.

The fruit fly is a good model for some of the cognitive defects in fragile X syndrome — but researchers sometimes find themselves having to defend their choice.