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Tag: ion channels

August 2021
Micrograph showing missing sodium ion channels in cerebral cortex of mice with two mutated copies of SCN2A gene.
News

Model mice hint at sodium channel gene’s contribution to autism

by  /  27 August 2021

Altered electrical activity in the neurons of mice with a mutated copy of SCN2A may explain the animals’ autism-like social behaviors.

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Images shows a pyramidal neuron.
News

How mutations in top autism gene could lead to seizures

by  /  5 August 2021

Deleterious mutations in an autism-associated gene can make neurons hyperexcitable, raising the risk of epileptic seizures.

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December 2020
Paper DNA with one torn base to signify a point mutation.
News

Analysis links 98 genes to neurodevelopmental conditions

by  /  10 December 2020

Genetic sequences from nearly 53,000 people with autism, developmental delay or intellectual disability reveal strong ties to 98 genes.

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October 2020
neurons in green.
News

Brain organoids reveal neuronal flaws in syndrome tied to autism

by  /  12 October 2020

Neurons derived from people with 22q11.2 deletion syndrome show deficits in calcium signaling and electrical activity, pointing to possible therapeutic targets.

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May 2020
News / Toolbox

Ultra-sensitive protein activates neurons in response to external light

by  /  27 May 2020

A new, minimally invasive technique allows researchers to activate neurons in the brains of mice and monkeys by using a light source located outside of the head.

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January 2020
neurons firing in black and white
News

Brain organoids may shed light on seizures in Angelman syndrome

by  /  22 January 2020

The mutation that causes Angelman syndrome makes neurons hyperexcitable, which may explain the frequent seizures that most people with the syndrome have.

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News / Toolbox

Artificial neurons may repair damaged cells and circuits

by  /  17 January 2020

Electronic neurons made from silicon mimic brain cells and could be used to treat conditions such as autism.

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May 2019
Child with Pitt-Hopkins syndrome seated in a red wagon outside.
Opinion

Pitt-Hopkins syndrome may point the way to autism treatments

by ,  /  1 May 2019

Researchers have identified a drug that works in individual cells and rodent models of a form of autism known as Pitt-Hopkins syndrome.

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September 2018
Mouse brain photograph shows the area of drug delivery highlighted in red.
News / Toolbox

Brain implant mutes seizure-like activity in mice

by  /  28 September 2018

A new brain implant pumps chemical signals directly into a target region to ease seizure-like activity in mice.

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April 2018
child with brain scan test
News

Top autism gene may alter sensory perception

by  /  16 April 2018

An unusual brain response to sound may distinguish children with mutations in SCN2A, a leading candidate gene for autism.

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