Tag: interneurons

August 2012
News

Epilepsy drug reverses autism-like symptoms in mice

by  /  27 August 2012

Researchers have homed in on the brain region thought to be responsible for the autism-like symptoms that can accompany Dravet syndrome, a rare epilepsy disorder, according to research published Wednesday in Nature.

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July 2012
News

Angelman mice show impaired inhibition of brain signals

by  /  2 July 2012

Mice lacking a functional copy of UBE3A, the gene missing or mutated in people with the rare developmental disorder Angelman syndrome, show less inhibitory activity than controls do, according to research published 7 June in Neuron.

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June 2012
News

Molecular mechanisms: Language neurons small in autism

by  /  13 June 2012

Neurons that activate signals in a brain region important for language and imitation are smaller in the brains of individuals with autism than in those of controls, according to a study published 31 March in Acta Neuropathology.

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January 2012
News / Toolbox

New technique charts patterns of microRNA expression

by  /  25 January 2012

Researchers have mapped the levels of tiny RNA fragments that regulate gene expression in specific brain regions and subtypes of neurons. The results were published 12 January in Neuron.  

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November 2011
News

Mouse models point to early troubles in tuberous sclerosis

by  /  28 November 2011

The brain abnormalities characteristic of tuberous sclerosis may begin early in development and involve malfunctioning of neuronal precursors, according to studies of two different mouse models of the disorder published in October.

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Opinion / Viewpoint

A case for the importance of interneurons in autism

by ,  /  22 November 2011

The etiology of autism may be best understood as an impairment of neuronal circuits, specifically interneurons that dampen signals in the brain, says neuroscientist Gordon Fishell.  

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News / Toolbox

Mouse lines light up the brain’s off switch

by  /  16 November 2011

Researchers have engineered 20 mouse lines that allow them to manipulate genes in specific neuronal circuits. The resource, reported 22 September in Neuron, will allow researchers to better explore the role of interneurons, which dampen signals in the brain, in mouse models of autism. 

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News

Subset of Rett gene’s targets may lead to the disorder

by  /  14 November 2011

Deleting the Rett syndrome gene in a subset of neurons, instead of throughout the body, dramatically lowers the number of genes that are dysregulated in those neurons, according to results presented in a poster session Saturday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.

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News

Vision problems in Rett syndrome could serve as biomarker

by  /  13 November 2011

Mice missing the Rett syndrome gene MeCP2 show a gradual decline in vision, and too much inhibitory signaling in the visual cortex, according to unpublished research presented Thursday in Washington, D.C.

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October 2011
News / Toolbox

Researchers engineer light-responsive strains of mice

by  /  5 October 2011

Researchers have engineered four new mouse lines that each show activation of a different subset of neurons in response to a blue light.

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