Vast diversity of human brain cell types revealed in trove of new datasets
The collection offers a glimpse into differences in cell composition — across people and brain regions — that may shape neural function.
The collection offers a glimpse into differences in cell composition — across people and brain regions — that may shape neural function.
After 10 years of work, Neurona may have the data to quiet its skeptics. But its ongoing clinical trial will be the ultimate test.
The inhibitory cells misfire and contribute to social difficulties in mice that model the syndrome.
Altered expression of TSC2 and the mTOR pathway reshape the formation of certain synapses between inhibitory and excitatory neurons in mice.
The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.
The method yields complex organoids that more closely mimic embryonic brain development than do those cultured in other ways.
People’s brains have a larger network of inhibitory interneurons than mouse brains do, according to a new study. Changes to that network could contribute to autism or other conditions, says lead investigator Moritz Helmstaedter.
The approach, tested in mice, selectively boosts the expression of the autism-linked gene SCN1A in a subgroup of inhibitory cells.
Interneurons that fail to propagate electrical signals in mice that model Dravet syndrome may cause the animals, like people with the autism-linked condition, to die suddenly.
Together, the neurons are part of the corticostriatal circuit, which has been implicated in autism.