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Spectrum: Autism Research News

Tag: intellectual disability

January 2021
DNMT3A protein attaches a methyl group tag onto the DNA base cytosine.

Autism-related conditions converge on same loss of DNA tags

by  /  20 January 2021

Mutations in the autism-linked gene DNMT3A lead to the behaviors and gene-expression changes seen in different neurodevelopmental conditions.

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3D glasses viewing a group fo people.

The promise of scientific partnerships with people on the spectrum

by  /  14 January 2021

Five collaborations involving autistic scientists and experts are advancing autism research, from lending support for theories of the condition to shoring up trials of new treatments.

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Two top autism genes may have a mechanism in common

by  /  13 January 2021

Mutations in two genes linked to autism and intellectual disability boost the immune response and cause synapse dysfunction.

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neurons in mice

Sensory perception, cell signals disrupted in people and mice missing autism gene

by  /  13 January 2021

People and mice with only one working copy of the autism gene SYNGAP1 may have trouble processing sights and sounds.

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December 2020
Micrograph of nerve cells being targeted by CRISPR enzyme to activate the silenced gene in Angelman syndrome

Hot topics in autism research, 2020

23 December 2020

The Spectrum team highlights five topics that distinguished autism research in 2020: diversity in data, gene therapies, subtyping, social circuitry and the ‘autism gene’ debate.

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Stylized DNA molecule

Mutations in the same exon linked to similar autism traits

by  /  17 December 2020

People with autism who carry DNA variants in the same protein-coding region of a gene have more similar cognitive abilities and behaviors than those who carry mutations in different regions of the same gene.

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Depressed teenager sitting on floor in darkened hallway.

Co-occurring psychiatric conditions put autistic people at risk for self-harm

by  /  11 December 2020

Autistic people are at an increased risk for intentional self-harm and death by suicide, but co-occurring psychiatric conditions may drive those behaviors.

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Paper DNA with one torn base to signify a point mutation.

Analysis links 98 genes to neurodevelopmental conditions

by  /  10 December 2020

Genetic sequences from nearly 53,000 people with autism, developmental delay or intellectual disability reveal strong ties to 98 genes.

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Cells transporting NCKAP1 protein in and out of nucleus

Rare variants tied to neuronal migration, autism traits

by  /  4 December 2020

Many people with mutations in the NCKAP1 gene have autism or autism traits, according to a new study spanning seven countries.

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November 2020
MRIs show changes over time

Big brain may mark subtype of autism

by  /  27 November 2020

Autistic boys with large brains in early childhood still have large brains in adolescence, challenging the long-standing idea that brain enlargement in autism is temporary.

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