A mathematical model of the brain’s circuits shows how neurons stuck in overdrive could produce symptoms of autism. The model may reveal how autism-linked behaviors arise from underlying biology.
Researchers have reconstructed in spectacular detail all of the complex circuits in a small piece of the mouse brain. They revealed the sublime images today in Cell.
Balls of neurons derived from skin cells of four boys with autism show shared alterations in biology and gene expression, researchers reported today in Cell. The findings finger FOXG1, a gene involved in brain development, as a player in autism.
Watch the complete replay of William Catterall explaining how low doses of an anxiety drug alleviate autism-like symptoms in mice.
Two new studies give a boost to arbaclofen, which failed to meet expectations in clinical trials for autism and fragile X syndrome.
Signals that relay sensations from nerves to the brain are abnormally strong in people with autism, a finding that may explain why some people with the disorder are overly sensitive to light, sound and touch.
A blood pressure drug called bumetanide may shield the brain from the effects of severe seizures early in life.
An ultra-thin and flexible electrode array can record brain signals without disturbing the underlying tissue.
Fetal mice that have too many neurons grow to show social deficits and repetitive behaviors. The finding, reported 11 December in Cell Reports, debuts a mouse model of autism that’s based on a biological abnormality seen in some people with the disorder.
Mice missing PTEN, a strong autism candidate gene, in a subtype of inhibitory neurons in one part of the brain show signaling abnormalities and social deficits. Researchers presented the unpublished work yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.