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Tag: inhibitory signaling

April 2015

Mouse studies support second chance for fragile X drug

by  /  28 April 2015

Two new studies give a boost to arbaclofen, which failed to meet expectations in clinical trials for autism and fragile X syndrome.


Brain connections give clues to sensory problems in autism

by  /  23 April 2015

Signals that relay sensations from nerves to the brain are abnormally strong in people with autism, a finding that may explain why some people with the disorder are overly sensitive to light, sound and touch.


Blood pressure drug may protect brain from seizures

by  /  7 April 2015

A blood pressure drug called bumetanide may shield the brain from the effects of severe seizures early in life.

February 2015
News / Toolbox

Flexible implant gently eavesdrops on brain signals

by  /  11 February 2015

An ultra-thin and flexible electrode array can record brain signals without disturbing the underlying tissue.

January 2015

Surplus of neurons spurs autism traits in mice

by  /  15 January 2015

Fetal mice that have too many neurons grow to show social deficits and repetitive behaviors. The finding, reported 11 December in Cell Reports, debuts a mouse model of autism that’s based on a biological abnormality seen in some people with the disorder.

November 2014

Autism-linked gene guides growth of subtype of neurons

by  /  19 November 2014

Mice missing PTEN, a strong autism candidate gene, in a subtype of inhibitory neurons in one part of the brain show signaling abnormalities and social deficits. Researchers presented the unpublished work yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.


Mimed gestures hint at repetitive behaviors in autism

by  /  15 November 2014

Children with autism show different patterns of brain activity during everyday gestures and movements than controls do, suggest unpublished results presented today at the 2014 Society for Neuroscience annual meeting in Washington, D.C.

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August 2014

Signaling imbalance skews sensory responses in autism mice

by  /  11 August 2014

Mice modeling autism have trouble integrating different kinds of sensory information such as sight, sound and touch. A study published 31 July in Neuron reports that an imbalance between signals that calm neurons and those that excite them leads to these sensory problems.

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July 2014

Mouse study nails neurons that trigger repetitive behavior

by  /  10 July 2014

A “beautiful” new study traces a complex repetitive behavior in a mouse model of autism to a subset of neurons in one brain region.

June 2014
Opinion / Viewpoint

How to evaluate new medications for autism

by  /  10 June 2014

There are no available medications for treating autism’s core symptoms, but there are several candidates in clinical trials. Jeremy Veenstra-VanderWeele describes the factors researchers must take into account when developing drugs for the disorder.