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Tag: inhibitory signaling

May 2014
News

Neurons that inhibit brain signals are key in Rett syndrome

by  /  5 May 2014

Deleting MeCP2 from a subset of neurons that mediate inhibitory signals recapitulates many of the symptoms of Rett syndrome in mice. Conversely, expressing the gene only in that subset, but not in the rest of the brain, protects the mice from some of those same symptoms. The results were published last week in Nature Neuroscience.

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April 2014
News / Toolbox

High-throughput screen finds genes that link neurons

by  /  30 April 2014

A new algorithm allows researchers to search among hundreds of genes and identify those involved in building synapses, the junctions that transmit signals between neurons, according to a report published 14 March in PLoS One.

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News

Low-dose sedative eases autism symptoms in mice

by  /  3 April 2014

The equivalent of one-tenth of a single pill of the anxiety drug clonazepam alleviates many autism-like behaviors in a mouse model of the disorder, according to a study published 19 March in Neuron.

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Opinion / Viewpoint

The cerebellum’s surprisingly evolved role in autism

by  /  1 April 2014

Thought until recently to only coordinate motor skills, the cerebellum is involved in diverse cognitive functions such as language and social interaction, and may play a role in autism, says Emanuel DiCicco-Bloom.

11 Comments
February 2014
News

Drug calms overly excitable brains in autism rodent models

by  /  10 February 2014

The blood pressure drug bumetanide normalizes a deficit in brain activity in two rodent models of autism, according to a study published last week in Science. The study hints at a mechanism underlying the drug’s benefits for people with autism.

5 Comments
January 2014
Multimedia / Webinars

Michael Merzenich discusses plasticity in autism

29 January 2014

Watch the complete replay of Michael Merzenich discussing how the brain’s ability to change with experience may lead to new treatments for autism.

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December 2013
Opinion / Viewpoint

Understanding contradictory connectivity reports in autism

by ,  /  10 December 2013

Studies at the level of neural circuits are needed to better understand the importance of both increased and decreased connectivity between different regions in the autism brain, say John Rubenstein and Vikaas Sohal.

1 Comment
November 2013
News / Toolbox

Neurons made directly from skin cells model autism mutations

by  /  27 November 2013

Skin cells taken from mice with an autism-linked mutation and transformed directly into neurons have the same properties as neurons from the brains of these mice. The study, published 8 October in Proceedings of the National Academy of Sciences, validates an efficient technique to study disease-linked mutations.

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Opinion / Viewpoint

More or less connected in autism, compared to what?

by  /  19 November 2013

Emerging findings in children with autism are showing both hyperconnectivity and underconnectivity in different regions and circuits throughout the brain.

2 Comments
News

New imaging method details brain abnormalities in mice

by  /  14 November 2013

A new imaging technique that can assemble finely detailed pictures of an individual mouse’s brain in less than a day is being used to explore mouse models of autism. Data from the first two models were presented Wednesday at the 2013 Society for Neuroscience annual meeting in San Diego.

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