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Tag: imprinting

August 2012
News

Nonprofit rallies funds to create autism-related mouse model

by  /  9 August 2012

Concerned by researchers’ lack of access to a valuable mouse model of autism, a nonprofit advocacy group is dedicating a chunk of its limited resources to the creation of a freely available version.

3 Comments
December 2011
News

Clinical research: Cancer drug could treat Angelman syndrome

by  /  21 December 2011

A cancer drug shows promise as a treatment for Angelman syndrome, according to a study published today in Nature.

0 Comments
November 2011
News

Researchers identify drug candidate for Angelman syndrome

by  /  17 November 2011

Researchers have identified a compound that shows promise as a treatment for Angelman syndrome, a developmental disorder related to autism. The unpublished results were presented Tuesday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.

7 Comments
October 2011
News

Two new autism mouse models highlight gene dosage effects

by  /  6 October 2011

Two new genetic mouse models that debuted this week show that having too many or too few copies of certain genetic regions leads to an array of symptoms reminiscent of autism.

6 Comments
September 2011
News / Toolbox

Reference set for Prader-Willi, Angelman syndromes debuts

by  /  14 September 2011

Researchers have developed standard genetic reference samples that clinicians can use to diagnose Angelman and Prader-Willi syndromes, two disorders associated with the same chromosomal region.

0 Comments
July 2011
Neurons
Opinion / Viewpoint

Insights for autism from Angelman syndrome

by , ,  /  19 July 2011

Deletions or duplications of the UBE3A gene lead to both Angelman syndrome and some cases of autism, respectively. Studying the effects of altered gene dosage in this region will provide insights into brain defects and suggest targets for therapies for both disorders, says expert Benjamin Philpot.

1 Comment
June 2011
News

Imperfect mouse may illuminate autism syndrome

by  /  30 June 2011

A new mouse model of 15q duplication syndrome, a genetic disorder associated with autism, falls short of recapitulating the symptoms of the syndrome. But it nonetheless points to a cluster of well-known risk genes as the most likely culprits.

2 Comments
May 2011
Opinion

Trendsetters

by  /  6 May 2011

Of 72 newly elected members of the National Academy of Sciences, 7 work either directly on autism or in related areas, illustrating the growing intellectual breadth and depth of the field.

0 Comments
March 2011
News

New candidate gene may explain male bias of autism

by  /  24 March 2011

A gene that regulates the conversion of testosterone to estrogen in the brain could help explain why males are more susceptible to autism than are females, according to a study published in PLoS One in February.

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February 2011
News

Genetics: Centrosome gene linked to autism

by  /  18 February 2011

Rare mutations in TSGA14, a component of the centrosome — which is required for the generation of new neurons — may be associated with autism, according to a study published in January in the American Journal of Medical Genetics.

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