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Spectrum: Autism Research News

Tag: hyperactivity

September 2012

Diagnosis eludes many girls with autism, study says

by  /  3 September 2012

Girls are less likely to be diagnosed with autism than boys are, unless they also have intellectual or behavioral problems, according to a study published 26 June in the Journal of the American Academy of Child and Adolescent Psychiatry.

August 2012

Executive confusion

by  /  21 August 2012

Among siblings of children with autism, those with better prefrontal cortex functioning — observable as relatively strong executive functions for their age — are better able to compensate for atypicalities in other brain systems early in life, and are therefore less likely to receive a diagnosis of autism later in their development, argues Mark H. Johnson.

June 2012

SHANK2 mouse models show opposite brain signaling

by  /  25 June 2012

Two new strains of mice carrying different mutations in the SHANK2 gene show similar autism-like behaviors but opposing effects on brain signaling, according to two independent studies published 14 June in Nature.


Microbial world

by  /  15 June 2012

New tools developed as part of the Human Microbiome Project could help researchers understand the role of microbes in autism.

May 2012

Molecular mechanisms: SHANK2, SHANK3 mouse brains differ

by  /  16 May 2012

Mice lacking the autism-associated gene SHANK2 show autism-like behaviors similar to those seen in mice lacking SHANK3, another member of the same gene family. But SHANK2 and SHANK3 mice have distinct alterations at neuronal junctions, according to a report published 29 April in Nature.


Better tools needed to assess clinical trials

by  /  14 May 2012

The past few years have seen an unprecedented number of clinical trials for experimental drugs to treat autism-related disorders, most notably for fragile X syndrome. But as the trials progress, scientists are calling for better methods to measure the drugs’ effectiveness.


Genetics: SHANK1 mutations found in men with autism

by  /  11 May 2012

Researchers have identified deletions in SHANK1 — the third member of a gene family that is closely linked to autism — in five men with the disorder, they reported 4 May in the American Journal of Human Genetics. This is the first study linking SHANK1 mutations to people with autism.


Biased search

by  /  1 May 2012

Publication bias is making antidepressants look like a better option for treating autism than they really are, according to a study published last week in Pediatrics.

April 2012

Chili pepper protein can alter behavior of mice

by  /  18 April 2012

By manipulating the location of a protein that detects capsaicin, the molecule responsible for the burn in hot chili peppers, researchers can activate subpopulations of neurons and alter the behavior of mice. The results were published 20 March in Nature Communications.

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Clinical research: Drug improves quality of life with autism

by  /  17 April 2012

Aripiprazole, a drug approved by the U.S. Food and Drug Administration to treat irritability in children with autism, may also improve their overall health-related quality of life, according to a retrospective analysis of two clinical trials. The results were published 21 March in Clinical Therapeutics.