Many of the genes that have emerged as the strongest autism candidates have turned out to regulate the expression of hundreds, if not thousands, of other genes. Within these networks, scientists are homing in on pathways that underlie autism.
Spectrum: Autism Research News
New estimates on the role of common mutations in autism raise questions about how to quantify and parse genetic risk. Three experts say both common and rare variants are worth pursuing.
Researchers have sequenced hundreds of human and mouse genomes to generate an atlas of more than 200,000 regions that regulate gene expression, they reported 27 March in Nature.
Mutations in TRIM33, a protein that is part of the cell’s cleanup crew, may up the risk for autism, according to a study published 5 November in Molecular Psychiatry.
More of the common variants implicated in schizophrenia are also linked to bipolar disorder than to autism, according to a study published 28 August in Nature Genetics.
A new statistical method for linking genes to a disorder analyzes both rare and common variants of a gene at the same time, according to a study published 14 May in the American Journal of Human Genetics. This makes it possible to confirm associations that other techniques might overlook.