A genome-wide association study lays a foundation for deeper investigation of these variants in neurodevelopmental conditions.
Spectrum: Autism Research News
Genes exert their strongest influence on the brain in the first half of gestation — a key window for autism and other neurodevelopmental conditions.
If a therapy for autism’s core traits makes it to market, it will likely take one of three forms, the researchers say.
Researchers know little about the ways genetic variants affect development in the infant brain. Knickmeyer, who launched the Organization for Imaging Genomics in Infancy, has spent the past five years trying to close the gap.
Psychiatric genomics promises to shed light on the genetic basis of autism, but it’s vital to include Africa in this research, Iyegbe and Okewole say.
The results highlight the importance of subgrouping study participants based on their underlying genetics, the researchers say.
The mutations occur spontaneously in noncoding stretches of DNA that control gene expression.
Women who carry genetic variants tied to autism have an elevated chance of experiencing pregnancy-related events linked to the condition in their children.
Deletion of the 22q11.2 chromosomal region alters the expression of numerous autism- and schizophrenia-linked genes, most of which are not contained within the deleted region, a new study suggests.
Genetic factors could help explain why the ‘social hormone’ failed to benefit autistic people in a phase 3 clinical trial last year.