Psychiatric genomics promises to shed light on the genetic basis of autism, but it’s vital to include Africa in this research, Iyegbe and Okewole say.
Spectrum: Autism Research News
The results highlight the importance of subgrouping study participants based on their underlying genetics, the researchers say.
The mutations occur spontaneously in noncoding stretches of DNA that control gene expression.
Women who carry genetic variants tied to autism have an elevated chance of experiencing pregnancy-related events linked to the condition in their children.
Deletion of the 22q11.2 chromosomal region alters the expression of numerous autism- and schizophrenia-linked genes, most of which are not contained within the deleted region, a new study suggests.
Genetic factors could help explain why the ‘social hormone’ failed to benefit autistic people in a phase 3 clinical trial last year.
The inflammation associated with the disease, particularly in mothers, may contribute to autism traits in children.
Scientists have at last filled in the missing gaps — an advance likely to inform every aspect of autism genetics research, Eichler says.
The X chromosome holds stronger-than-expected genetic sway over the structure of several brain regions. The genes that may underlie this oversized influence have ties to autism.