The many genes implicated in Williams syndrome, a condition related to autism, may all work together to exert their effects on behavior.

The duplication of a chromosomal region missing in people with Williams syndrome is associated with separation anxiety, according to a study published 8 June in The American Journal of Human Genetics.

Mouse pups with a duplication of GTF2I, a gene linked to Williams syndrome and autism, show extreme separation anxiety when separated from their mothers, according to unpublished findings presented Thursday at the International Congress of Human Genetics in Montreal, Canada.

Mice lacking one copy of a gene associated with Williams syndrome share the hyper-sociability of people with the disorder, according to a paper published online 3 December in Autism Research.

A mouse model of Williams syndrome pinpoints a genetic region associated with the social behavior seen in the disorder, and may also yield insights into autism, says researcher Uta Francke, professor emeritus of genetics at Stanford University.

Studying the relatively well-defined genetics of Williams syndrome may help unravel the poorly understood genetic and neurobiological roots of autism, researchers say.