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Tag: glutamate

June 2021
Mouse neuron recordings showing different levels of activity before and after an encounter with an unfamiliar mouse.
News

Neural network captures noisy neurons in autism mouse model

by  /  18 June 2021

Mice missing the autism-linked gene SHANK3 use more neurons to engage in social behavior than control mice do, reflecting a more disorganized, less efficient brain signaling network.

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May 2021
Visual stimulus of 4 circles with black and white stripes.
News

Visual task flags autistic people who respond to GABA agonists

by  /  14 May 2021

The investigational drug arbaclofen makes autistic people’s brains respond to a visual task more like non-autistic people’s brains do.

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brainstem of rats in red, green and blue highlight higher levels of GABA.
News

GABA agonist rescues auditory hypersensitivity in rats missing autism-linked gene CNTNAP2

by  /  3 May 2021

The investigational drug arbaclofen may right an imbalance between inhibitory and excitatory signaling in the animals’ brains.

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July 2019
News

Family groups, researchers join forces to solve mysteries of autism gene

by  /  10 July 2019

Families of children with mutations in a gene called SYNGAP1 have spurred research into the effects of the mutations on people — and how to treat them.

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May 2019
News

The signaling imbalance theory of autism, explained

by  /  1 May 2019

The signaling imbalance theory holds that the brains of autistic people are hyper-excitable because of either excess neuronal activity or weak brakes on that activity.

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September 2018
Artwork shows a flock of birds flying inside the head of a boy.
Opinion / Viewpoint

How a ‘pacemaker’ for the brain could ease autism traits

by  /  4 September 2018

Looking at the brain as a whole suggests that nudging flawed sets of neurons to collaborate better might alleviate autism traits.

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July 2018
A whimsical illustration shows scientists as flowers, being 'watered' by Euros, which is also filtering down into a system of lab objects and medicines.
News

Record-breaking grant may fuel autism drug development

by  /  19 July 2018

A huge new research collaboration may jump-start the race to develop therapies for autism.

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February 2018
colorful hands marking a path
News

Twist on gene-editing tool may speed studies of gene function

by  /  21 February 2018

Researchers have repurposed the gene-editing tool CRISPR to dial down a gene’s activity in select subtypes of neurons in mice.

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January 2018
Mice lacking one copy of MEF2C have fewer neurons (red and green, right) in the hippocampus than controls do (left).
News

Modified Alzheimer’s drug may treat some forms of autism

by  /  18 January 2018

A fusion of two existing drugs alleviates autism-like features in a mouse model of the condition.

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November 2017
Mapping the connections between brain regions in mice can reveal which ones are strengthened by a drug.
News

Mouse imaging study hints at how fragile X drug trial went wrong

by  /  15 November 2017

The drug mavoglurant has no effect on a brain circuit involved in social behavior in a mouse model of fragile X syndrome. That may explain its poor performance in people with the condition.

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